FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047775825> ?p ?o ?g. }

• W2047775825 endingPage "322" @default.
• W2047775825 startingPage "315" @default.
• W2047775825 abstract "SUMMARY Detergent extracts of Trypanosoma cruzi epimastigotes catalysed the hydrolysis of a range of amino-acyl and peptidyl p-nitro-anilides and aminomethylcoumarins. At least three enzymes were detected that cleave Z–Phe–Arg–MCA. Two of these were optimally active at alkaline pH, the other at pH 4·0. Of the two enzymes with alkaline pH optima, one was a cysteine peptidase and was unable to cleave Bz–Arg–MCA readily, whilst the other cleaved Bz–Arg–MCA and was inhibited by diisopropyl fluorophosphate. The acidic enzyme was similar to cathespin L of other eukayrotes with respect to its pH profile, substrate-specificity and inhibitor-sensitivity. Evidence was presented that epimastigotes contain a cysteine-type dipeptidyl aminopeptidase, one or more aminopeptidases, and a serine peptidase that cleaves Boc–Ala–Ala–pNA. Digitonin solubilization of the activities from cells supports the hypothesis that the cathespin L-like enzyme and the dipeptidyl aminopeptidase are lysosomal, whilst the Bz–Arg–MCA hydrolase, the aminopeptidases and the Boc–Ala–Ala–pNA serine peptidase are cytosolic." @default.
• W2047775825 created "2016-06-24" @default.
• W2047775825 creator A5002878160 @default.
• W2047775825 creator A5010660351 @default.
• W2047775825 creator A5024228085 @default.
• W2047775825 creator A5030281417 @default.
• W2047775825 creator A5035118081 @default.
• W2047775825 creator A5080720904 @default.
• W2047775825 creator A5091533167 @default.
• W2047775825 date "1992-04-01" @default.
• W2047775825 modified "2023-10-18" @default.
• W2047775825 title "Detection of peptidases inTrypanosoma cruziepimastigotes using chromogenic and fluorogenic substrates" @default.
• W2047775825 cites W1484675846 @default.
• W2047775825 cites W1493252203 @default.
• W2047775825 cites W1501665702 @default.
• W2047775825 cites W1966497279 @default.
• W2047775825 cites W1985469117 @default.
• W2047775825 cites W1991957381 @default.
• W2047775825 cites W1994628900 @default.
• W2047775825 cites W2009480854 @default.
• W2047775825 cites W2025304612 @default.
• W2047775825 cites W2029434796 @default.
• W2047775825 cites W2030928762 @default.
• W2047775825 cites W2040180992 @default.
• W2047775825 cites W2055329059 @default.
• W2047775825 cites W2070687039 @default.
• W2047775825 cites W2071378403 @default.
• W2047775825 cites W2086470002 @default.
• W2047775825 cites W2086679893 @default.
• W2047775825 cites W2093337390 @default.
• W2047775825 cites W2093366365 @default.
• W2047775825 cites W2200791553 @default.
• W2047775825 cites W4293247451 @default.
• W2047775825 doi "https://doi.org/10.1017/s003118200006176x" @default.
• W2047775825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1594295" @default.
• W2047775825 hasPublicationYear "1992" @default.
• W2047775825 type Work @default.
• W2047775825 sameAs 2047775825 @default.
• W2047775825 citedByCount "11" @default.
• W2047775825 countsByYear W20477758252016 @default.
• W2047775825 countsByYear W20477758252023 @default.
• W2047775825 crossrefType "journal-article" @default.
• W2047775825 hasAuthorship W2047775825A5002878160 @default.
• W2047775825 hasAuthorship W2047775825A5010660351 @default.
• W2047775825 hasAuthorship W2047775825A5024228085 @default.
• W2047775825 hasAuthorship W2047775825A5030281417 @default.
• W2047775825 hasAuthorship W2047775825A5035118081 @default.
• W2047775825 hasAuthorship W2047775825A5080720904 @default.
• W2047775825 hasAuthorship W2047775825A5091533167 @default.
• W2047775825 hasConcept C181199279 @default.
• W2047775825 hasConcept C182220744 @default.
• W2047775825 hasConcept C2775883766 @default.
• W2047775825 hasConcept C2776414213 @default.
• W2047775825 hasConcept C2776580952 @default.
• W2047775825 hasConcept C2776714187 @default.
• W2047775825 hasConcept C2776873056 @default.
• W2047775825 hasConcept C2777807008 @default.
• W2047775825 hasConcept C2779201268 @default.
• W2047775825 hasConcept C2780985610 @default.
• W2047775825 hasConcept C2781378782 @default.
• W2047775825 hasConcept C2781469919 @default.
• W2047775825 hasConcept C515207424 @default.
• W2047775825 hasConcept C55493867 @default.
• W2047775825 hasConcept C86803240 @default.
• W2047775825 hasConceptScore W2047775825C181199279 @default.
• W2047775825 hasConceptScore W2047775825C182220744 @default.
• W2047775825 hasConceptScore W2047775825C2775883766 @default.
• W2047775825 hasConceptScore W2047775825C2776414213 @default.
• W2047775825 hasConceptScore W2047775825C2776580952 @default.
• W2047775825 hasConceptScore W2047775825C2776714187 @default.
• W2047775825 hasConceptScore W2047775825C2776873056 @default.
• W2047775825 hasConceptScore W2047775825C2777807008 @default.
• W2047775825 hasConceptScore W2047775825C2779201268 @default.
• W2047775825 hasConceptScore W2047775825C2780985610 @default.
• W2047775825 hasConceptScore W2047775825C2781378782 @default.
• W2047775825 hasConceptScore W2047775825C2781469919 @default.
• W2047775825 hasConceptScore W2047775825C515207424 @default.
• W2047775825 hasConceptScore W2047775825C55493867 @default.
• W2047775825 hasConceptScore W2047775825C86803240 @default.
• W2047775825 hasIssue "2" @default.
• W2047775825 hasLocation W20477758251 @default.
• W2047775825 hasLocation W20477758252 @default.
• W2047775825 hasOpenAccess W2047775825 @default.
• W2047775825 hasPrimaryLocation W20477758251 @default.
• W2047775825 hasRelatedWork W2047775825 @default.
• W2047775825 hasRelatedWork W2047971925 @default.
• W2047775825 hasRelatedWork W2051916785 @default.
• W2047775825 hasRelatedWork W2076932799 @default.
• W2047775825 hasRelatedWork W2085694096 @default.
• W2047775825 hasRelatedWork W2322933242 @default.
• W2047775825 hasRelatedWork W2465575984 @default.
• W2047775825 hasRelatedWork W2566267702 @default.
• W2047775825 hasRelatedWork W2950584035 @default.
• W2047775825 hasRelatedWork W2182658384 @default.
• W2047775825 hasVolume "104" @default.
• W2047775825 isParatext "false" @default.
• W2047775825 isRetracted "false" @default.
• W2047775825 magId "2047775825" @default.

• next