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• W2047804529 endingPage "1196" @default.
• W2047804529 startingPage "1192" @default.
• W2047804529 abstract "DNA repair by nonhomologous end-joining (NHEJ) relies on the Ku70:Ku80 heterodimer in species ranging from yeast to man. In Saccharomyces cerevisiae and Schizosaccharomyces pombe, Ku also controls telomere functions. Here, we show that Ku70, Ku80, and DNA-PKcs, with which Ku interacts, associate in vivo with telomeric DNA in several human cell types, and we show that these associations are not significantly affected by DNA-damaging agents. We also demonstrate that inactivation of Ku80 or Ku70 in the mouse yields telomeric shortening in various primary cell types at different developmental stages. By contrast, telomere length is not altered in cells impaired in XRCC4 or DNA ligase IV, two other NHEJ components. We also observe higher genomic instability in Ku-deficient cells than in XRCC4-null cells. This suggests that chromosomal instability of Ku-deficient cells results from a combination of compromised telomere stability and defective NHEJ." @default.
• W2047804529 created "2016-06-24" @default.
• W2047804529 creator A5006766331 @default.
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• W2047804529 date "2001-08-01" @default.
• W2047804529 modified "2023-10-16" @default.
• W2047804529 title "Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells" @default.
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• W2047804529 doi "https://doi.org/10.1016/s0960-9822(01)00328-1" @default.
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• W2047804529 hasPublicationYear "2001" @default.
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