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- W2047816152 abstract "Hypoxia Hypoxia refers to below-normal levels of oxygen in air, blood, or tissue. Tissue hypoxia leads to cellular dysfunction and ultimately can lead to cell death. Causes of tissue hypoxia include (a) decreased blood oxygenation (such as occurs in certain pulmonary disorders), (b) altered oxygen release from hemoglobin (associated with some hemoglobinopathies), and (c) impaired blood delivery leading to localized anemia (i.e., ischemia) as a result of low cardiac output or vascular obstruction. In order to adapt to hypoxia, mammals use a number of physiological responses. These include (a) increased production of erythropoietin (EPO), which augments the production of red blood cells; (b) induction of tyrosine hydroxylase, which facilitates the control of ventilation through the carotid body; and (c) the stimulation of new blood vessels by upregulation of VEGF (1). At the cellular level, hypoxia induces a number of metabolic changes that allow for continued energy generation despite decreased oxygen availability." @default.
- W2047816152 created "2016-06-24" @default.
- W2047816152 creator A5057859390 @default.
- W2047816152 creator A5088456751 @default.
- W2047816152 date "2003-03-15" @default.
- W2047816152 modified "2023-10-18" @default.
- W2047816152 title "HIF hydroxylation and the mammalian oxygen-sensing pathway" @default.
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- W2047816152 cites W1514961004 @default.
- W2047816152 cites W1529290897 @default.
- W2047816152 cites W1543034080 @default.
- W2047816152 cites W1543110198 @default.
- W2047816152 cites W1575392692 @default.
- W2047816152 cites W1590774636 @default.
- W2047816152 cites W1606390515 @default.
- W2047816152 cites W1749022239 @default.
- W2047816152 cites W1780308454 @default.
- W2047816152 cites W1895938869 @default.
- W2047816152 cites W1963533810 @default.
- W2047816152 cites W1964037605 @default.
- W2047816152 cites W1972009030 @default.
- W2047816152 cites W1972032694 @default.
- W2047816152 cites W1973092951 @default.
- W2047816152 cites W1975545468 @default.
- W2047816152 cites W1975984062 @default.
- W2047816152 cites W1978173977 @default.
- W2047816152 cites W1986464453 @default.
- W2047816152 cites W1988935612 @default.
- W2047816152 cites W1989040551 @default.
- W2047816152 cites W1993608966 @default.
- W2047816152 cites W1995684639 @default.
- W2047816152 cites W2005868568 @default.
- W2047816152 cites W2006622472 @default.
- W2047816152 cites W2006833515 @default.
- W2047816152 cites W2010160635 @default.
- W2047816152 cites W2010394923 @default.
- W2047816152 cites W2011562442 @default.
- W2047816152 cites W2015817451 @default.
- W2047816152 cites W2017902734 @default.
- W2047816152 cites W2021932335 @default.
- W2047816152 cites W2028400858 @default.
- W2047816152 cites W2040031153 @default.
- W2047816152 cites W2042216712 @default.
- W2047816152 cites W2042702043 @default.
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- W2047816152 cites W2068555261 @default.
- W2047816152 cites W2076145832 @default.
- W2047816152 cites W2080374319 @default.
- W2047816152 cites W2081460564 @default.
- W2047816152 cites W2082493554 @default.
- W2047816152 cites W2085609942 @default.
- W2047816152 cites W2086812941 @default.
- W2047816152 cites W2087841059 @default.
- W2047816152 cites W2089692551 @default.
- W2047816152 cites W2094611185 @default.
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- W2047816152 cites W2107751591 @default.
- W2047816152 cites W2108366666 @default.
- W2047816152 cites W2126440077 @default.
- W2047816152 cites W2130933110 @default.
- W2047816152 cites W2140496726 @default.
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- W2047816152 cites W2144625075 @default.
- W2047816152 cites W2145023430 @default.
- W2047816152 cites W2145610465 @default.
- W2047816152 cites W2147718842 @default.
- W2047816152 cites W2149268957 @default.
- W2047816152 cites W2149960175 @default.
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- W2047816152 cites W2153584576 @default.
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- W2047816152 cites W2172170481 @default.
- W2047816152 cites W2177184392 @default.
- W2047816152 cites W2291715419 @default.
- W2047816152 cites W2317428842 @default.
- W2047816152 cites W2330854723 @default.
- W2047816152 cites W2596045242 @default.
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- W2047816152 doi "https://doi.org/10.1172/jci18181" @default.
- W2047816152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/153778" @default.
- W2047816152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12639980" @default.
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