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• W2047816292 abstract "Lymphotoxin-alpha (LTA) polymorphism rs909253 has been reported to be a risk factor for cancers, but some results are inconsistent. To establish a more conclusive association, we performed a meta-analysis of this variant with cancers. A systematic search was performed for informative case-control studies of rs909253 with cancers among literature databases, including PubMed, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), and Wanfang Chinese Periodical Database. After a comprehensive filtration procedure, 36 publications involved with 35,677 participants were selected for the current meta-analysis. Stratified factors, such as cancer type, populations, and source of control, were used for a better interpretation of this variant. Minimal heterogeneity was shown in the current meta-analysis (I (2) = 0.0%, P = 0.48). Our results show a significant association of rs909253 and cancer risk (odds ratio (OR) = 1.12, P (z) < 0.001). In the subgroup analysis, significant association of rs909253 was found in adenocarcinoma (OR = 1.16, P (z) < 0.001) and hematological malignancy (OR = 1.10, P (z) < 0.001). Our meta-analyses established a significant association of rs909253 with cancer risk among multiple populations including North Americans, Asians, and Europeans." @default.
• W2047816292 created "2016-06-24" @default.
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• W2047816292 creator A5063168393 @default.
• W2047816292 creator A5085663161 @default.
• W2047816292 date "2013-10-18" @default.
• W2047816292 modified "2023-09-24" @default.
• W2047816292 title "Positive association between lymphotoxin-alpha variation rs909253 and cancer risk: a meta-analysis based on 36 case–control studies" @default.
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• W2047816292 doi "https://doi.org/10.1007/s13277-013-1263-4" @default.
• W2047816292 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24136744" @default.
• W2047816292 hasPublicationYear "2013" @default.
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