FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047829571> ?p ?o ?g. }

• W2047829571 endingPage "615" @default.
• W2047829571 startingPage "604" @default.
• W2047829571 abstract "The extracellular concentrations of glutamate and its co-agonist for the N-methyl-d-aspartate (NMDA) receptor, glycine, may be under the control of amino acid transporters in the ischemic brain, However, there is little information on changes in glycine and glutamate transporters in the hippocampal CA1 field of gerbils with transient forebrain ischemia. This study investigated the spatial and temporal expressions of glycine transporter 1 (GLYT 1) and three glutamate transporter (excitatory amino acid carrier 1, EAAC 1; glutamate/aspartate transporter, GLAST; glutamate transporter 1, GLT1) mRNA in the gerbil hippocampus after 3 minutes of ischemia. The GLYT1 mRNA was transiently upregulated by the second day after ischemia in astrocytelike cells in close vicinity to hippocampal CA1 pyramidal neurons, possibly to reduce glycine concentration in the local extracellular spaces. The EAAC1 mRNA was abundantly expressed in almost all pyramidal neurons and dentate granule cells in the control gerbil hippocampus, whereas the expression level in CA1 pyramidal neurons started to decrease by the fourth day after ischemia in synchrony with degeneration of the CA1 neurons. The GLAST and GLT1 mRNA were rather intensely expressed in the dentate gyrus and CA3 field of the control hippocampus, respectively, but they were weakly expressed in the CA1 field before and after ischemia. As GLAST and GLT1 play a major role in the control of extracellular glutamate concentration, the paucity of these transporters in the CA1 field may account for the vulnerability of CA1 neurons to ischemia, provided that the functional GLAST and GLT1 proteins are also less in the CA1 field than in the CA3 field. This study suggests that the amino acid transporters play pivotal roles in the process of delayed neuronal death in the hippocampal CA1 field." @default.
• W2047829571 created "2016-06-24" @default.
• W2047829571 creator A5001774118 @default.
• W2047829571 creator A5008989957 @default.
• W2047829571 creator A5026408372 @default.
• W2047829571 creator A5065800084 @default.
• W2047829571 creator A5091736516 @default.
• W2047829571 date "1999-06-01" @default.
• W2047829571 modified "2023-10-04" @default.
• W2047829571 title "Differential Expressions of Glycine Transporter 1 and Three Glutamate Transporter mRNA in the Hippocampus of Gerbils with Transient Forebrain Ischemia" @default.
• W2047829571 cites W1491108164 @default.
• W2047829571 cites W1629378997 @default.
• W2047829571 cites W1900227502 @default.
• W2047829571 cites W1911169303 @default.
• W2047829571 cites W1940843357 @default.
• W2047829571 cites W1964306102 @default.
• W2047829571 cites W1968563892 @default.
• W2047829571 cites W1969400861 @default.
• W2047829571 cites W1978726693 @default.
• W2047829571 cites W1980723823 @default.
• W2047829571 cites W1983197885 @default.
• W2047829571 cites W1984277246 @default.
• W2047829571 cites W1991701465 @default.
• W2047829571 cites W2002090821 @default.
• W2047829571 cites W2003410399 @default.
• W2047829571 cites W2005392747 @default.
• W2047829571 cites W2010926499 @default.
• W2047829571 cites W2013605211 @default.
• W2047829571 cites W2013995428 @default.
• W2047829571 cites W2016071574 @default.
• W2047829571 cites W2018177128 @default.
• W2047829571 cites W2019974245 @default.
• W2047829571 cites W2020622209 @default.
• W2047829571 cites W2021473153 @default.
• W2047829571 cites W2024173492 @default.
• W2047829571 cites W2030205285 @default.
• W2047829571 cites W2030352252 @default.
• W2047829571 cites W2035750459 @default.
• W2047829571 cites W2045391337 @default.
• W2047829571 cites W2057459594 @default.
• W2047829571 cites W2060049453 @default.
• W2047829571 cites W2066281989 @default.
• W2047829571 cites W2070338276 @default.
• W2047829571 cites W2072078981 @default.
• W2047829571 cites W2085519854 @default.
• W2047829571 cites W2085995558 @default.
• W2047829571 cites W2086731122 @default.
• W2047829571 cites W2087568162 @default.
• W2047829571 cites W2088514907 @default.
• W2047829571 cites W2091097006 @default.
• W2047829571 cites W2092358916 @default.
• W2047829571 cites W2095546791 @default.
• W2047829571 cites W2114010161 @default.
• W2047829571 cites W2121792692 @default.
• W2047829571 cites W2128744963 @default.
• W2047829571 cites W2163314018 @default.
• W2047829571 cites W2165030901 @default.
• W2047829571 cites W2309703157 @default.
• W2047829571 cites W2401650200 @default.
• W2047829571 doi "https://doi.org/10.1097/00004647-199906000-00003" @default.
• W2047829571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10366190" @default.
• W2047829571 hasPublicationYear "1999" @default.
• W2047829571 type Work @default.
• W2047829571 sameAs 2047829571 @default.
• W2047829571 citedByCount "41" @default.
• W2047829571 countsByYear W20478295712012 @default.
• W2047829571 countsByYear W20478295712013 @default.
• W2047829571 countsByYear W20478295712015 @default.
• W2047829571 countsByYear W20478295712016 @default.
• W2047829571 countsByYear W20478295712018 @default.
• W2047829571 countsByYear W20478295712019 @default.
• W2047829571 countsByYear W20478295712020 @default.
• W2047829571 countsByYear W20478295712021 @default.
• W2047829571 countsByYear W20478295712023 @default.
• W2047829571 crossrefType "journal-article" @default.
• W2047829571 hasAuthorship W2047829571A5001774118 @default.
• W2047829571 hasAuthorship W2047829571A5008989957 @default.
• W2047829571 hasAuthorship W2047829571A5026408372 @default.
• W2047829571 hasAuthorship W2047829571A5065800084 @default.
• W2047829571 hasAuthorship W2047829571A5091736516 @default.
• W2047829571 hasBestOaLocation W20478295711 @default.
• W2047829571 hasConcept C126322002 @default.
• W2047829571 hasConcept C134018914 @default.
• W2047829571 hasConcept C148762608 @default.
• W2047829571 hasConcept C156310829 @default.
• W2047829571 hasConcept C169760540 @default.
• W2047829571 hasConcept C170493617 @default.
• W2047829571 hasConcept C185592680 @default.
• W2047829571 hasConcept C2776464000 @default.
• W2047829571 hasConcept C2781012912 @default.
• W2047829571 hasConcept C2781161787 @default.
• W2047829571 hasConcept C49051014 @default.
• W2047829571 hasConcept C55493867 @default.
• W2047829571 hasConcept C61174792 @default.
• W2047829571 hasConcept C67018056 @default.
• W2047829571 hasConcept C71924100 @default.
• W2047829571 hasConcept C86803240 @default.
• W2047829571 hasConcept C95444343 @default.

• next