FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047834008> ?p ?o ?g. }

• W2047834008 endingPage "527" @default.
• W2047834008 startingPage "513" @default.
• W2047834008 abstract "The glucocorticoid signaling pathway is responsive to a considerable number of internal and external signals and can therefore establish diverse patterns of gene expression. A glial-specific pattern, for example, is shown by the glucocorticoid-inducible gene glutamine synthetase. The enzyme is expressed at a particularly high level in glial cells, where it catalyzes the recycling of the neurotransmitter glutamate, and at a low level in most other cells, for housekeeping duties. Glial specificity of glutamine synthetase induction is achieved by the use of positive and negative regulatory elements, a glucocorticoid response element and a neural restrictive silencer element. Though not glial specific by themselves, these elements may establish a glial-specific pattern of expression through their mutual activity and their combined effect. The inductive activity of glucocorticoids is markedly repressed by the c-Jun protein, which is expressed at relatively high levels in proliferating glial cells. The signaling pathway of c-Jun is activated by the disruption of glia-neuron cell contacts, by transformation with v-src, and in proliferating retinal cells of early embryonic ages. The c-Jun protein inhibits the transcriptional activity of the glucocorticoid receptor and thus represses glutamine synthetase expression. This repressive mechanism might also affect the ability of glial cells to cope with glutamate neurotoxicity in injured tissues." @default.
• W2047834008 created "2016-06-24" @default.
• W2047834008 creator A5003357043 @default.
• W2047834008 creator A5004077628 @default.
• W2047834008 creator A5033474942 @default.
• W2047834008 creator A5034073756 @default.
• W2047834008 creator A5084783108 @default.
• W2047834008 date "1999-09-15" @default.
• W2047834008 modified "2023-09-25" @default.
• W2047834008 title "Glucocorticoid control of glial gene expression" @default.
• W2047834008 cites W1483685331 @default.
• W2047834008 cites W1495790002 @default.
• W2047834008 cites W1527082041 @default.
• W2047834008 cites W1532921926 @default.
• W2047834008 cites W1600992751 @default.
• W2047834008 cites W1602041200 @default.
• W2047834008 cites W1764369687 @default.
• W2047834008 cites W1805618930 @default.
• W2047834008 cites W1824239451 @default.
• W2047834008 cites W1835285123 @default.
• W2047834008 cites W1934163786 @default.
• W2047834008 cites W1966229762 @default.
• W2047834008 cites W1967081763 @default.
• W2047834008 cites W1968074908 @default.
• W2047834008 cites W1969013108 @default.
• W2047834008 cites W1972181454 @default.
• W2047834008 cites W1972754545 @default.
• W2047834008 cites W1973227158 @default.
• W2047834008 cites W1973234053 @default.
• W2047834008 cites W1974190613 @default.
• W2047834008 cites W1974779070 @default.
• W2047834008 cites W1974782102 @default.
• W2047834008 cites W1974999120 @default.
• W2047834008 cites W1975256513 @default.
• W2047834008 cites W1975682643 @default.
• W2047834008 cites W1976775201 @default.
• W2047834008 cites W1977130958 @default.
• W2047834008 cites W1980722886 @default.
• W2047834008 cites W1981834071 @default.
• W2047834008 cites W1982976347 @default.
• W2047834008 cites W1984089779 @default.
• W2047834008 cites W1985132050 @default.
• W2047834008 cites W1985300178 @default.
• W2047834008 cites W1985331071 @default.
• W2047834008 cites W1987080089 @default.
• W2047834008 cites W1987557547 @default.
• W2047834008 cites W1990170863 @default.
• W2047834008 cites W1995865634 @default.
• W2047834008 cites W1996207504 @default.
• W2047834008 cites W1996499858 @default.
• W2047834008 cites W2000490360 @default.
• W2047834008 cites W2001676436 @default.
• W2047834008 cites W2006835527 @default.
• W2047834008 cites W2008804581 @default.
• W2047834008 cites W2009385541 @default.
• W2047834008 cites W2011100121 @default.
• W2047834008 cites W2011144057 @default.
• W2047834008 cites W2013326699 @default.
• W2047834008 cites W2015613847 @default.
• W2047834008 cites W2015830945 @default.
• W2047834008 cites W2018534859 @default.
• W2047834008 cites W2018569342 @default.
• W2047834008 cites W2021036849 @default.
• W2047834008 cites W2021678912 @default.
• W2047834008 cites W2024670087 @default.
• W2047834008 cites W2027269358 @default.
• W2047834008 cites W2029310025 @default.
• W2047834008 cites W2030163218 @default.
• W2047834008 cites W2031596923 @default.
• W2047834008 cites W2031667205 @default.
• W2047834008 cites W2033276499 @default.
• W2047834008 cites W2036475318 @default.
• W2047834008 cites W2036536120 @default.
• W2047834008 cites W2037390777 @default.
• W2047834008 cites W2038630479 @default.
• W2047834008 cites W2041247329 @default.
• W2047834008 cites W2041611159 @default.
• W2047834008 cites W2041848662 @default.
• W2047834008 cites W2042550512 @default.
• W2047834008 cites W2043389104 @default.
• W2047834008 cites W2043439651 @default.
• W2047834008 cites W2050006662 @default.
• W2047834008 cites W2050330538 @default.
• W2047834008 cites W2052850418 @default.
• W2047834008 cites W2053929310 @default.
• W2047834008 cites W2055869088 @default.
• W2047834008 cites W2056401491 @default.
• W2047834008 cites W2057459864 @default.
• W2047834008 cites W2058868228 @default.
• W2047834008 cites W2059750980 @default.
• W2047834008 cites W2061079524 @default.
• W2047834008 cites W2062435931 @default.
• W2047834008 cites W2062703157 @default.
• W2047834008 cites W2062810674 @default.
• W2047834008 cites W2064072791 @default.
• W2047834008 cites W2065098992 @default.
• W2047834008 cites W2065417429 @default.
• W2047834008 cites W2066017487 @default.

• next