Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047836890> ?p ?o ?g. }
- W2047836890 endingPage "831" @default.
- W2047836890 startingPage "821" @default.
- W2047836890 abstract "Ischemic preconditioning, a robust cardioprotective intervention, has limited clinical efficacy because it must be initiated before myocardial ischemia. Conversely, ischemic postconditioning, repeated brief reocclusions of a coronary artery after release of prolonged coronary occlusion, provides cardioprotection in clinically feasible settings, that is, coronary angioplasty. Ischemic postconditioning's signaling is being investigated to identify pharmacological triggers that could be used without angioplasty. In initial minutes of reperfusion H+ washes out of previously ischemic cells. pH rises enabling mitochondrial permeability transition pores (MPTPs) to form leading to cessation of ATP production and cell necrosis. Coronary reocclusions maintain sufficient acidosis to keep MPTP closed while signaling is initiated that can generate endogenous antagonists of MPTP formation even after cellular pH normalizes. Reintroduction of oxygen generates reactive oxygen species that activate protein kinase C to increase sensitivity of adenosine A2b receptors allowing adenosine released from ischemic cells to bind leading to activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2. Phosphatidylinositol 3-kinase activation results in phosphorylation of Akt promoting activation of nitric oxide synthase and nitric oxide production, which inhibits glycogen synthase kinase-3β, perhaps the final cytosolic signaling step before inhibition of MPTP formation. Interference with MPTP may be the final step that determines cell salvage. Antioxid. Redox Signal. 14, 821–831." @default.
- W2047836890 created "2016-06-24" @default.
- W2047836890 creator A5023127517 @default.
- W2047836890 creator A5051850889 @default.
- W2047836890 date "2011-03-01" @default.
- W2047836890 modified "2023-09-24" @default.
- W2047836890 title "Ischemic Postconditioning: From Receptor to End-Effector" @default.
- W2047836890 cites W1507410890 @default.
- W2047836890 cites W1582253391 @default.
- W2047836890 cites W1607892649 @default.
- W2047836890 cites W1851055496 @default.
- W2047836890 cites W1894853873 @default.
- W2047836890 cites W1964292228 @default.
- W2047836890 cites W1964483580 @default.
- W2047836890 cites W1965480868 @default.
- W2047836890 cites W1967184826 @default.
- W2047836890 cites W1974718425 @default.
- W2047836890 cites W1976713885 @default.
- W2047836890 cites W1985927695 @default.
- W2047836890 cites W1986161535 @default.
- W2047836890 cites W1987664769 @default.
- W2047836890 cites W1994234605 @default.
- W2047836890 cites W1996867825 @default.
- W2047836890 cites W2001189110 @default.
- W2047836890 cites W2004462169 @default.
- W2047836890 cites W2007294454 @default.
- W2047836890 cites W2009032298 @default.
- W2047836890 cites W2010512593 @default.
- W2047836890 cites W2010516222 @default.
- W2047836890 cites W2013968205 @default.
- W2047836890 cites W2021111465 @default.
- W2047836890 cites W2021733224 @default.
- W2047836890 cites W2022131685 @default.
- W2047836890 cites W2023269956 @default.
- W2047836890 cites W2025077643 @default.
- W2047836890 cites W2025155186 @default.
- W2047836890 cites W2026977120 @default.
- W2047836890 cites W2029077404 @default.
- W2047836890 cites W2038445476 @default.
- W2047836890 cites W2044609399 @default.
- W2047836890 cites W2049043910 @default.
- W2047836890 cites W2049149064 @default.
- W2047836890 cites W2049460661 @default.
- W2047836890 cites W2052231299 @default.
- W2047836890 cites W2054903524 @default.
- W2047836890 cites W2055674941 @default.
- W2047836890 cites W2056507950 @default.
- W2047836890 cites W2057257618 @default.
- W2047836890 cites W2061365466 @default.
- W2047836890 cites W2076951580 @default.
- W2047836890 cites W2081787098 @default.
- W2047836890 cites W2089446697 @default.
- W2047836890 cites W2092914889 @default.
- W2047836890 cites W2103918111 @default.
- W2047836890 cites W2114429287 @default.
- W2047836890 cites W2116603854 @default.
- W2047836890 cites W2116899872 @default.
- W2047836890 cites W2124027170 @default.
- W2047836890 cites W2126788226 @default.
- W2047836890 cites W2131015734 @default.
- W2047836890 cites W2137445925 @default.
- W2047836890 cites W2140040255 @default.
- W2047836890 cites W2140766624 @default.
- W2047836890 cites W2143762484 @default.
- W2047836890 cites W2146217294 @default.
- W2047836890 cites W2147640676 @default.
- W2047836890 cites W2147791296 @default.
- W2047836890 cites W2148706434 @default.
- W2047836890 cites W2150021667 @default.
- W2047836890 cites W2151589110 @default.
- W2047836890 cites W2153298328 @default.
- W2047836890 cites W2163768568 @default.
- W2047836890 cites W2167953429 @default.
- W2047836890 cites W2170347547 @default.
- W2047836890 cites W2171073677 @default.
- W2047836890 cites W2318664368 @default.
- W2047836890 cites W2331299102 @default.
- W2047836890 cites W4240150566 @default.
- W2047836890 doi "https://doi.org/10.1089/ars.2010.3318" @default.
- W2047836890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20518705" @default.
- W2047836890 hasPublicationYear "2011" @default.
- W2047836890 type Work @default.
- W2047836890 sameAs 2047836890 @default.
- W2047836890 citedByCount "86" @default.
- W2047836890 countsByYear W20478368902012 @default.
- W2047836890 countsByYear W20478368902013 @default.
- W2047836890 countsByYear W20478368902014 @default.
- W2047836890 countsByYear W20478368902015 @default.
- W2047836890 countsByYear W20478368902016 @default.
- W2047836890 countsByYear W20478368902017 @default.
- W2047836890 countsByYear W20478368902018 @default.
- W2047836890 countsByYear W20478368902019 @default.
- W2047836890 countsByYear W20478368902020 @default.
- W2047836890 countsByYear W20478368902021 @default.
- W2047836890 countsByYear W20478368902022 @default.
- W2047836890 countsByYear W20478368902023 @default.
- W2047836890 crossrefType "journal-article" @default.
- W2047836890 hasAuthorship W2047836890A5023127517 @default.