Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047849079> ?p ?o ?g. }
- W2047849079 endingPage "775" @default.
- W2047849079 startingPage "767" @default.
- W2047849079 abstract "A number of previous reviews have very eloquently summarized pain models and endpoints in animals. Many of these reviews also discuss how animal models have enhanced our understanding of pain mechanisms and make forward-looking statements as to our proximity to the development of effective mechanism-based treatments. While a number of reports cite failures of animal pain models to predict efficacy in humans, few have actually analyzed where these models have been successful. This review gives a brief overview of those successes, both backward, providing validation of the models, and forward, predicting clinical efficacy. While the largest dataset is presented on treatments for neuropathic pain, this review also discusses acute and inflammatory pain models. Key to prediction of clinical efficacy is a lack of side effects, which may incorrectly suggest efficacy in animals and an understanding of how pharmacokinetic parameters translate from animals to man. As such, this review focuses on a description of the pharmacokinetic-pharmacodynamic relationship for a number of pain treatments that are effective in both animals and humans. Finally we discuss where and why animal pain models have failed and summarize improvements to pain models that should expand and improve their predictive power." @default.
- W2047849079 created "2016-06-24" @default.
- W2047849079 creator A5014090723 @default.
- W2047849079 creator A5024179300 @default.
- W2047849079 creator A5074731229 @default.
- W2047849079 date "2008-04-01" @default.
- W2047849079 modified "2023-10-08" @default.
- W2047849079 title "Predictive validity of animal pain models? A comparison of the pharmacokinetic–pharmacodynamic relationship for pain drugs in rats and humans" @default.
- W2047849079 cites W1896223819 @default.
- W2047849079 cites W1965318376 @default.
- W2047849079 cites W1965592684 @default.
- W2047849079 cites W1971234076 @default.
- W2047849079 cites W1971857467 @default.
- W2047849079 cites W1979468189 @default.
- W2047849079 cites W1981475715 @default.
- W2047849079 cites W1984754203 @default.
- W2047849079 cites W1986367282 @default.
- W2047849079 cites W1988790334 @default.
- W2047849079 cites W1992518420 @default.
- W2047849079 cites W1997500507 @default.
- W2047849079 cites W2003549933 @default.
- W2047849079 cites W2004323875 @default.
- W2047849079 cites W2010787925 @default.
- W2047849079 cites W2015362668 @default.
- W2047849079 cites W2015395924 @default.
- W2047849079 cites W2018656586 @default.
- W2047849079 cites W2021167114 @default.
- W2047849079 cites W2024083302 @default.
- W2047849079 cites W2028186017 @default.
- W2047849079 cites W2030086862 @default.
- W2047849079 cites W2031521709 @default.
- W2047849079 cites W2033438673 @default.
- W2047849079 cites W2039286479 @default.
- W2047849079 cites W2039871355 @default.
- W2047849079 cites W2041140288 @default.
- W2047849079 cites W2043883181 @default.
- W2047849079 cites W2049802977 @default.
- W2047849079 cites W2050707182 @default.
- W2047849079 cites W2053067012 @default.
- W2047849079 cites W2056173439 @default.
- W2047849079 cites W2059661753 @default.
- W2047849079 cites W2060280732 @default.
- W2047849079 cites W2063103164 @default.
- W2047849079 cites W2066064086 @default.
- W2047849079 cites W2066796908 @default.
- W2047849079 cites W2067212451 @default.
- W2047849079 cites W2072876787 @default.
- W2047849079 cites W2072968157 @default.
- W2047849079 cites W2074563786 @default.
- W2047849079 cites W2077506348 @default.
- W2047849079 cites W2079080132 @default.
- W2047849079 cites W2079428232 @default.
- W2047849079 cites W2087411783 @default.
- W2047849079 cites W2088422411 @default.
- W2047849079 cites W2088858180 @default.
- W2047849079 cites W2092766960 @default.
- W2047849079 cites W2099854799 @default.
- W2047849079 cites W2101362870 @default.
- W2047849079 cites W2101464778 @default.
- W2047849079 cites W2104600881 @default.
- W2047849079 cites W2106753138 @default.
- W2047849079 cites W2106807118 @default.
- W2047849079 cites W2111265419 @default.
- W2047849079 cites W2124985912 @default.
- W2047849079 cites W2128887654 @default.
- W2047849079 cites W2136828073 @default.
- W2047849079 cites W2137264859 @default.
- W2047849079 cites W2141947204 @default.
- W2047849079 cites W2159904602 @default.
- W2047849079 cites W2163138945 @default.
- W2047849079 cites W2164144654 @default.
- W2047849079 cites W2169906005 @default.
- W2047849079 cites W2170380292 @default.
- W2047849079 cites W4231722380 @default.
- W2047849079 doi "https://doi.org/10.1016/j.neuropharm.2008.01.001" @default.
- W2047849079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18289614" @default.
- W2047849079 hasPublicationYear "2008" @default.
- W2047849079 type Work @default.
- W2047849079 sameAs 2047849079 @default.
- W2047849079 citedByCount "117" @default.
- W2047849079 countsByYear W20478490792012 @default.
- W2047849079 countsByYear W20478490792013 @default.
- W2047849079 countsByYear W20478490792014 @default.
- W2047849079 countsByYear W20478490792015 @default.
- W2047849079 countsByYear W20478490792016 @default.
- W2047849079 countsByYear W20478490792017 @default.
- W2047849079 countsByYear W20478490792018 @default.
- W2047849079 countsByYear W20478490792019 @default.
- W2047849079 countsByYear W20478490792020 @default.
- W2047849079 countsByYear W20478490792021 @default.
- W2047849079 countsByYear W20478490792022 @default.
- W2047849079 countsByYear W20478490792023 @default.
- W2047849079 crossrefType "journal-article" @default.
- W2047849079 hasAuthorship W2047849079A5014090723 @default.
- W2047849079 hasAuthorship W2047849079A5024179300 @default.
- W2047849079 hasAuthorship W2047849079A5074731229 @default.
- W2047849079 hasConcept C111113717 @default.
- W2047849079 hasConcept C112705442 @default.