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- W2047858047 abstract "Abstract Cell adhesion is a vital process, essential for the establishment and maintenance of tissue architecture and differentiation. Cadherins are a large family of cell adhesion molecules, which mediate cell–cell adhesion via calcium dependent, homotypic interactions. These molecules have intra- and extracellular domains, which are integral to the mechanism of cell adhesion. The intracellular domains interact with catenins, which link the cadherins to the actin cytoskeleton. Alterations in either of these groups of molecules have been identified as key mechanisms in various disease processes. Complex alterations in adhesion have been proposed as a requirement for tumour invasion and metastases. Similar alterations in adhesive properties have been proposed as a mechanism for blistering skin diseases. The literature abounds with evidence, based on molecular studies and immunohistochemistry, implicating the cadherin–catenin complex in human disease. Evaluation of the cadherin–catenin complex in malignant tumours has improved our understanding of tumour invasion and metastases. In addition, it may provide important prognostic information and may hold answers for future therapeutic intervention." @default.
- W2047858047 created "2016-06-24" @default.
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- W2047858047 date "2002-10-01" @default.
- W2047858047 modified "2023-09-28" @default.
- W2047858047 title "Cadherins and catenins in pathology" @default.
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- W2047858047 doi "https://doi.org/10.1054/cdip.2002.0132" @default.
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