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• W2047865631 abstract "Necrosis and apoptosis caused by ischaemia–reperfusion (IR) result in myocyte death and atrophy. ATP-sensitive K+ (KATP) channels activation increases tissue tolerance of IR-injury. Thus, in the present study, we evaluated the effects of KATP channel activation on skeletal muscle apoptosis after IR. Male Wistar rats were treated with 40 mg/kg, i.p., diazoxide (a KATP channel opener) or 5 mg/kg, i.p., glibenclamide (a KATP channel inhibitor) 30 min before the induction of 3 h ischaemia, followed by 6, 24 or 48 h reperfusion. At the end of the reperfusion period, the gastrocnemius muscle was removed for the analysis of tissue malondialdehyde content, superoxide dismutase (SOD) and catalase (CAT) activity, Bax and Bcl-2 protein expression, histological damage and the number of apoptotic nuclei. Ischaemia–reperfusion increased malondialdehyde content (P < 0.01) and Bax expression (P < 0.01) and induced severe histological damage, in addition to decreasing CAT and SOD activity (P < 0.01 and P < 0.05, respectively) and Bcl-2 expression (P < 0.01). Diazoxide reversed the effects of IR on tissue damage, MDA content, SOD and CAT activity (after 6 and 24 h reperfusion; P < 0.05) and Bax and Bcl-2 expression (after 24 and 48 h reperfusion; P < 0.01). In contrast, glibenclamide pretreatment had no effect. The number of apoptotic nuclei in the IR and glibenclamide-pretreated groups increased significantly (P < 0.001 vs Sham). In contrast, diazoxide pretreatment decreased the number of apoptotic nuclei compared with the IR group (P < 0.01). The results of the present study suggest that the KATP channel activator diazoxide attenuates lipid peroxidation during the first hour of reperfusion and modulates apoptotic pathways at later time points." @default.
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• W2047865631 date "2012-10-29" @default.
• W2047865631 modified "2023-10-18" @default.
• W2047865631 title "Late anti-apoptotic effect of KATPchannel opening in skeletal muscle" @default.
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• W2047865631 doi "https://doi.org/10.1111/1440-1681.12015" @default.
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