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• W2047877973 abstract "Tibolone is a synthetic steroid with mixed estrogenic and progestogenic/androgenic activity used for post-menopausal hormone replacement therapy. Since its cardiovascular effects are still not clear, and no data have been published on possible direct actions on the vessel wall, we studied the effects of tibolone and its metabolites on lipopolysaccharide (LPS)-induced expression of leukocyte adhesion molecules on human endothelial cells. Tibolone and its two estrogenic 3alpha-OH and 3beta-OH metabolites, but not the progestogenic/androgenic Delta(4)-isomer, concentration-dependently decreased LPS-induced vascular cell adhesion molecule-1 protein expression. This effect was estrogen receptor dependent, since it was completely blocked by the pure estrogen receptor antagonist ICI 182780. Furthermore, only tibolone, the 3alpha-OH and the 3beta-OH metabolites decreased endothelial expression of E-selectin, while none of the compounds changed the levels of intercellular adhesion molecule-1. These findings were associated with parallel changes in mRNA levels for the three adhesion molecules. Our data show that tibolone and its estrogenic metabolites exert direct actions on the vascular wall, decreasing the expression of endothelial-leukocyte adhesion molecules, thus producing potentially important direct anti-atherogenic effects." @default.
• W2047877973 created "2016-06-24" @default.
• W2047877973 creator A5004083793 @default.
• W2047877973 creator A5038322094 @default.
• W2047877973 date "2000-04-01" @default.
• W2047877973 modified "2023-10-18" @default.
• W2047877973 title "Tibolone inhibits leukocyte adhesion molecule expression in human endothelial cells" @default.
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• W2047877973 doi "https://doi.org/10.1016/s0303-7207(00)00206-9" @default.
• W2047877973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10854701" @default.
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