FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047878418> ?p ?o ?g. }

• W2047878418 endingPage "68" @default.
• W2047878418 startingPage "61" @default.
• W2047878418 abstract "Transforming growth factor beta and basic fibroblast growth factor are multipotential factors found in bone and cartilage that may be involved in both the proliferation and differentiation of chondrocytes. It was previously reported that TGF-β plus FGF caused a modulation of chondrocyte phenotype that included the downregulation of steady-state level of the collagen II transcript. In this report, the results of nuclear run-off data indicate that repression of transcript initiation from the collagen II gene is the primary mechanism involved in the growth factor induced inhibition. Transient transfection assays with CAT expression vectors containing portions of the collagen II gene show that the TGF-β/FGF induced transrepression requires a region in the first intron previously reported to have transcriptional enhancer activity and to bind chondrocyte nuclear proteins. In addition, silencer elements in the promoter also appear to play a role. Protein data as well as transient transfection experiments indicate that the activation of protein kinase C is necessary for the growth factor–induced down-regulation of collagen II expression. These studies suggest that a cascade initiating with PKC activation is responsible for modifying transcription factors that interact with regulatory sequences in the collagen II gene. A detailed understanding of the factors involved in cartilage-specific gene regulation in chondrocytes would facilitate development of therapeutic protocols for the repair of degenerated cartilage in diseases such as osteoarthritis. © 1994 Wiley-Liss, Inc." @default.
• W2047878418 created "2016-06-24" @default.
• W2047878418 creator A5010132216 @default.
• W2047878418 creator A5012596134 @default.
• W2047878418 creator A5058914459 @default.
• W2047878418 creator A5075179691 @default.
• W2047878418 creator A5075238712 @default.
• W2047878418 date "1994-01-01" @default.
• W2047878418 modified "2023-10-17" @default.
• W2047878418 title "Transrepression of type II collagen by TGF-? and FGF is protein kinase C dependent and is mediated through regulatory sequences in the promoter and first intron" @default.
• W2047878418 cites W1480727199 @default.
• W2047878418 cites W1488751005 @default.
• W2047878418 cites W1496494806 @default.
• W2047878418 cites W1509400195 @default.
• W2047878418 cites W1519773895 @default.
• W2047878418 cites W1542431794 @default.
• W2047878418 cites W1573828669 @default.
• W2047878418 cites W1596660137 @default.
• W2047878418 cites W1655258255 @default.
• W2047878418 cites W1780824832 @default.
• W2047878418 cites W1965372133 @default.
• W2047878418 cites W1974831021 @default.
• W2047878418 cites W1977302628 @default.
• W2047878418 cites W1985457327 @default.
• W2047878418 cites W1987757198 @default.
• W2047878418 cites W1994552438 @default.
• W2047878418 cites W1994858403 @default.
• W2047878418 cites W2002468800 @default.
• W2047878418 cites W2003632139 @default.
• W2047878418 cites W2011015637 @default.
• W2047878418 cites W2012744197 @default.
• W2047878418 cites W2016703353 @default.
• W2047878418 cites W2019050177 @default.
• W2047878418 cites W2019727181 @default.
• W2047878418 cites W2021253208 @default.
• W2047878418 cites W2023251607 @default.
• W2047878418 cites W2036823562 @default.
• W2047878418 cites W2039897595 @default.
• W2047878418 cites W2050999934 @default.
• W2047878418 cites W2080960719 @default.
• W2047878418 cites W2082670705 @default.
• W2047878418 cites W2082797919 @default.
• W2047878418 cites W2086352112 @default.
• W2047878418 cites W2093107754 @default.
• W2047878418 cites W2096904163 @default.
• W2047878418 cites W2099600512 @default.
• W2047878418 cites W2130535740 @default.
• W2047878418 cites W2136131491 @default.
• W2047878418 cites W2143227037 @default.
• W2047878418 cites W2144206181 @default.
• W2047878418 cites W337230970 @default.
• W2047878418 doi "https://doi.org/10.1002/jcp.1041580109" @default.
• W2047878418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8263029" @default.
• W2047878418 hasPublicationYear "1994" @default.
• W2047878418 type Work @default.
• W2047878418 sameAs 2047878418 @default.
• W2047878418 citedByCount "32" @default.
• W2047878418 countsByYear W20478784182012 @default.
• W2047878418 countsByYear W20478784182013 @default.
• W2047878418 countsByYear W20478784182015 @default.
• W2047878418 countsByYear W20478784182016 @default.
• W2047878418 crossrefType "journal-article" @default.
• W2047878418 hasAuthorship W2047878418A5010132216 @default.
• W2047878418 hasAuthorship W2047878418A5012596134 @default.
• W2047878418 hasAuthorship W2047878418A5058914459 @default.
• W2047878418 hasAuthorship W2047878418A5075179691 @default.
• W2047878418 hasAuthorship W2047878418A5075238712 @default.
• W2047878418 hasConcept C104317684 @default.
• W2047878418 hasConcept C105702510 @default.
• W2047878418 hasConcept C111936080 @default.
• W2047878418 hasConcept C153911025 @default.
• W2047878418 hasConcept C170493617 @default.
• W2047878418 hasConcept C185592680 @default.
• W2047878418 hasConcept C195794163 @default.
• W2047878418 hasConcept C2775960820 @default.
• W2047878418 hasConcept C2780550940 @default.
• W2047878418 hasConcept C2781013607 @default.
• W2047878418 hasConcept C2781403057 @default.
• W2047878418 hasConcept C54355233 @default.
• W2047878418 hasConcept C62478195 @default.
• W2047878418 hasConcept C74373430 @default.
• W2047878418 hasConcept C86339819 @default.
• W2047878418 hasConcept C86803240 @default.
• W2047878418 hasConcept C95444343 @default.
• W2047878418 hasConceptScore W2047878418C104317684 @default.
• W2047878418 hasConceptScore W2047878418C105702510 @default.
• W2047878418 hasConceptScore W2047878418C111936080 @default.
• W2047878418 hasConceptScore W2047878418C153911025 @default.
• W2047878418 hasConceptScore W2047878418C170493617 @default.
• W2047878418 hasConceptScore W2047878418C185592680 @default.
• W2047878418 hasConceptScore W2047878418C195794163 @default.
• W2047878418 hasConceptScore W2047878418C2775960820 @default.
• W2047878418 hasConceptScore W2047878418C2780550940 @default.
• W2047878418 hasConceptScore W2047878418C2781013607 @default.
• W2047878418 hasConceptScore W2047878418C2781403057 @default.
• W2047878418 hasConceptScore W2047878418C54355233 @default.
• W2047878418 hasConceptScore W2047878418C62478195 @default.
• W2047878418 hasConceptScore W2047878418C74373430 @default.

• next