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• W2047878442 abstract "Multiunit or single unit activity recorded simultaneously from frontal cortex (FC) and locus coeruleus (LC) under ketamine anesthesia revealed that both regions show slow oscillatory activity, together or separately. If, however, both regions are engaged in this oscillatory activity, there is a systematic relationship between their phases with peak LC firing always following FC firing by 200-400 ms. This was confirmed by cross-correlational analyses, which indicated that the two structures temporarily form a resonant system. The FC-LC resonant state is, however, loose enough to remain open to other intrinsic or extrinsic influences, keeping the measured frequencies of oscillations at each site slightly different, as demonstrated by a detailed analysis of the autocorrelograms. An injection of lidocaine at the frontal cortex site, while sharply reducing the prefrontal activity to essentially zero, leads to an increase of the LC activity and to a modification of the shape of the LC autocorrelogram, but does not change appreciably the phase relationship between the activity in the two structures during the diminishing activity in FC." @default.
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• W2047878442 date "1997-12-01" @default.
• W2047878442 modified "2023-09-27" @default.
• W2047878442 title "Slow oscillations as a probe of the dynamics of the locus coeruleus-frontal cortex interaction in anesthetized rats" @default.
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• W2047878442 doi "https://doi.org/10.1016/s0928-4257(97)82407-2" @default.
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