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• W2047883928 abstract "To elucidate the relationship between epidermal growth factor (EGF)/transforming growth factor (TGF-α) and estradiol-17β (E) in cell proliferation, we examined their effects on the breast cancer cell line, CAMA-1. While E was able to consistently induce cell proliferation under a variety of experimental conditions, EGF/TGF-α was without effect. Despite the presence of the receptor (EGFR) gene, mature EGFR protein and mRNA were not detected by radioreceptor assay, 35S Met-labelling, and the Intron Differential RNA/PCR method under conditions in which cells remain responsive to E. Furthermore, TGF-α is not an autocrine factor in CAMA-1 cells. We demonstrated unequivocally that EGF/TGF-α interaction with EGFR is not an obligatory event in mediating estrogen-stimulated cell proliferation." @default.
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• W2047883928 date "1991-06-01" @default.
• W2047883928 modified "2023-10-17" @default.
• W2047883928 title "Evidence of an EGF/TGF-α—independent pathway for estrogen-regulated cell proliferation" @default.
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• W2047883928 doi "https://doi.org/10.1002/jcb.240460206" @default.
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