FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047885038> ?p ?o ?g. }

• W2047885038 endingPage "157" @default.
• W2047885038 startingPage "147" @default.
• W2047885038 abstract "Objective : The aim of this study was to review the results of dynamic pituitary testing in patients presenting with fatigue. Methods : We reviewed clinical histories and insulin tolerance test (ITT) results of 59 patients who presented with fatigue and other symptoms of glucocorticoid insufficiency over a 4-year period. All patients referred for ITT had an early-morning cortisol level of <400 nM and a low or normal ACTH level. Results : Peak cortisol and GH responses following insulin-induced hypoglycaemia were normal in only seven patients (12%). Median age of the remaining 52 patients was 47 years (range, 17–67 years); all but five were female. Common presenting symptoms were neuroglycopaenia ( n = 47), depression ( n = 37), arthralgia and myalgia ( n = 28), weight gain ( n = 25), weight loss ( n = 9), postural dizziness ( n = 15) and headaches ( n = 13). Other medical history included autoimmune disease ( n = 20; particularly Hashimoto’s thyroiditis, Graves’ disease and coeliac disease), postpartum ( n = 8) and gastrointestinal ( n = 2) haemorrhage and hyperprolactinaemia ( n = 13). 31 subjects had peak cortisol levels of <500 nM (suggestive of ACTH deficiency; 18 of whom had levels < 400 nM) and a further six had indeterminate results (500–550 nM). The remaining 15 subjects had normal cortisol responses (median 654 nM; range, 553–1062 nM) but had low GH levels following hypoglycaemic stimulation (5.9 mU/l; 3–11.6 mU/l). Conclusion : Our results suggest that patients presenting with fatigue and symptoms suggestive of hypocortisolism should be considered for screening for secondary adrenal insufficiency, particularly in the presence of autoimmune disease or a history of postpartum or gastrointestinal haemorrhage. Whether physiological glucocorticoid replacement improves symptoms in this patient group is yet to be established." @default.
• W2047885038 created "2016-06-24" @default.
• W2047885038 creator A5001212969 @default.
• W2047885038 creator A5072557977 @default.
• W2047885038 date "2006-01-01" @default.
• W2047885038 modified "2023-10-17" @default.
• W2047885038 title "Evaluation of pituitary function in the fatigued patient: a review of 59 cases" @default.
• W2047885038 cites W1561351730 @default.
• W2047885038 cites W1964615849 @default.
• W2047885038 cites W1966700213 @default.
• W2047885038 cites W1975906537 @default.
• W2047885038 cites W1977561446 @default.
• W2047885038 cites W1979298977 @default.
• W2047885038 cites W1986930279 @default.
• W2047885038 cites W1995110885 @default.
• W2047885038 cites W2002802702 @default.
• W2047885038 cites W2010542304 @default.
• W2047885038 cites W2011001772 @default.
• W2047885038 cites W2016904498 @default.
• W2047885038 cites W2017605705 @default.
• W2047885038 cites W2021176276 @default.
• W2047885038 cites W2035098906 @default.
• W2047885038 cites W2040450568 @default.
• W2047885038 cites W2043809625 @default.
• W2047885038 cites W2048325369 @default.
• W2047885038 cites W2053022640 @default.
• W2047885038 cites W2067594067 @default.
• W2047885038 cites W2069215403 @default.
• W2047885038 cites W2078447609 @default.
• W2047885038 cites W2079609895 @default.
• W2047885038 cites W2080326796 @default.
• W2047885038 cites W2089433743 @default.
• W2047885038 cites W2094221378 @default.
• W2047885038 cites W2101288743 @default.
• W2047885038 cites W2104456269 @default.
• W2047885038 cites W2107816350 @default.
• W2047885038 cites W2115568720 @default.
• W2047885038 cites W2116224445 @default.
• W2047885038 cites W2136248223 @default.
• W2047885038 cites W2147071446 @default.
• W2047885038 cites W2148024817 @default.
• W2047885038 cites W2156505367 @default.
• W2047885038 cites W2157428281 @default.
• W2047885038 cites W2163533066 @default.
• W2047885038 cites W2323478895 @default.
• W2047885038 cites W2329267332 @default.
• W2047885038 cites W2606513528 @default.
• W2047885038 cites W2625822193 @default.
• W2047885038 cites W4211192934 @default.
• W2047885038 cites W4230444312 @default.
• W2047885038 cites W4232899611 @default.
• W2047885038 cites W4240928453 @default.
• W2047885038 cites W4241240192 @default.
• W2047885038 cites W4255274953 @default.
• W2047885038 cites W4376595548 @default.
• W2047885038 doi "https://doi.org/10.1530/eje.1.02010" @default.
• W2047885038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16382004" @default.
• W2047885038 hasPublicationYear "2006" @default.
• W2047885038 type Work @default.
• W2047885038 sameAs 2047885038 @default.
• W2047885038 citedByCount "10" @default.
• W2047885038 countsByYear W20478850382012 @default.
• W2047885038 countsByYear W20478850382013 @default.
• W2047885038 countsByYear W20478850382018 @default.
• W2047885038 crossrefType "journal-article" @default.
• W2047885038 hasAuthorship W2047885038A5001212969 @default.
• W2047885038 hasAuthorship W2047885038A5072557977 @default.
• W2047885038 hasBestOaLocation W20478850381 @default.
• W2047885038 hasConcept C126322002 @default.
• W2047885038 hasConcept C134018914 @default.
• W2047885038 hasConcept C139719470 @default.
• W2047885038 hasConcept C141071460 @default.
• W2047885038 hasConcept C162324750 @default.
• W2047885038 hasConcept C2776867660 @default.
• W2047885038 hasConcept C2777391703 @default.
• W2047885038 hasConcept C2778129406 @default.
• W2047885038 hasConcept C2778616394 @default.
• W2047885038 hasConcept C2778696486 @default.
• W2047885038 hasConcept C2779064019 @default.
• W2047885038 hasConcept C2779113265 @default.
• W2047885038 hasConcept C2779134260 @default.
• W2047885038 hasConcept C2779306644 @default.
• W2047885038 hasConcept C2780966972 @default.
• W2047885038 hasConcept C2781401123 @default.
• W2047885038 hasConcept C2910141127 @default.
• W2047885038 hasConcept C3017594256 @default.
• W2047885038 hasConcept C71315377 @default.
• W2047885038 hasConcept C71924100 @default.
• W2047885038 hasConcept C90924648 @default.
• W2047885038 hasConceptScore W2047885038C126322002 @default.
• W2047885038 hasConceptScore W2047885038C134018914 @default.
• W2047885038 hasConceptScore W2047885038C139719470 @default.
• W2047885038 hasConceptScore W2047885038C141071460 @default.
• W2047885038 hasConceptScore W2047885038C162324750 @default.
• W2047885038 hasConceptScore W2047885038C2776867660 @default.
• W2047885038 hasConceptScore W2047885038C2777391703 @default.
• W2047885038 hasConceptScore W2047885038C2778129406 @default.
• W2047885038 hasConceptScore W2047885038C2778616394 @default.

• next