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- W2047885736 abstract "Abstract Single injections of dihydroergocristine (dhe) (25, 50 and 100 μg, i.p.) did not depress the systemic arterial pressure but antagonized the pressor effects of (-)-noradrenaline (100 μg, s.c.) in unanaesthetized rats. The effects of these doses of dhe on water diuresis were minimal: slight K retention, a rise in urinary Na:K and a slight but significant fall in the clearance of p-aminohippuric acid were noted. Single injections of phentolamine mesylate (10, 20 and 40 μg, i.p.) greatly depressed systemic arterial pressure and reduced the glomerular filtration rate and p-aminohippuric acid clearance and the excretion of water and Na proportionately, but markedly. The Na:K in the urine rose. Chemical denervation of the kidneys either with dhe, 32 μg, or phentolamine, 2 mg, thrice daily for 5–7 days decreased, but for 14 days increased, the juxtaglomerular index of the kidneys. Parallel changes were found in the extractable renin. Continued treatment with dhe (32 μg thrice daily for 2 weeks) raised, and hyperduric adrenaline (250 μg twice daily for 1 week) lowered the stores of growth hormone in the adenohypophysis. Continued treatment with dhe, 32 μg thrice daily produced antidiuresis and retention by the third day lasting to the fifth. This condition had reversed by the eighth day." @default.
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- W2047885736 date "1969-10-01" @default.
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- W2047885736 title "Some effects of dihydroergocristine and of phentolamine mesylate on renal function in rats" @default.
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- W2047885736 doi "https://doi.org/10.1111/j.2042-7158.1969.tb08140.x" @default.
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