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• W2047908311 endingPage "61" @default.
• W2047908311 startingPage "48" @default.
• W2047908311 abstract "Progesterone is a well-known steroid hormone, synthesized by ovaries and placenta in females, and by adrenal glands in both males and females. Several tissues are targets of progesterone and the nervous system is a major one. Progesterone is also locally synthesized by the nervous system and qualifies, therefore, as a neurosteroid. In addition, the nervous system has the capacity to bio-convert progesterone into its active metabolite allopregnanolone. The enzymes required for progesterone and allopregnanolone synthesis are widely distributed in brain and spinal cord. Increased local biosynthesis of pregnenolone, progesterone and 5α-dihydroprogesterone may be a part of an endogenous neuroprotective mechanism in response to nervous system injuries. Progesterone and allopregnanolone neuroprotective effects have been widely recognized. Multiple receptors or associated proteins may contribute to the progesterone effects: classical nuclear receptors (PR), membrane progesterone receptor component 1 (PGRMC1), membrane progesterone receptors (mPR), and γ-aminobutyric acid type A (GABAA) receptors after conversion to allopregnanolone. In this review, we will succinctly describe progesterone and allopregnanolone biosynthetic pathways and enzyme distribution in brain and spinal cord. Then, we will summarize our work on progesterone receptor distribution and cellular expression in brain and spinal cord; neurosteroid stimulation after nervous system injuries (spinal cord injury, traumatic brain injury, and stroke); and on progesterone and allopregnanolone neuroprotective effects in different experimental models including stroke and spinal cord injury. We will discuss in detail the neuroprotective effects of progesterone on the nervous system via PR, and of allopregnanolone via its modulation of GABAA receptors." @default.
• W2047908311 created "2016-06-24" @default.
• W2047908311 creator A5010070272 @default.
• W2047908311 creator A5017772564 @default.
• W2047908311 creator A5021025335 @default.
• W2047908311 creator A5029189004 @default.
• W2047908311 creator A5033533800 @default.
• W2047908311 creator A5063712209 @default.
• W2047908311 date "2015-02-01" @default.
• W2047908311 modified "2023-10-06" @default.
• W2047908311 title "Progesterone and allopregnanolone in the central nervous system: Response to injury and implication for neuroprotection" @default.
• W2047908311 cites W1502906763 @default.
• W2047908311 cites W1555821924 @default.
• W2047908311 cites W1559593467 @default.
• W2047908311 cites W1564265454 @default.
• W2047908311 cites W1569704074 @default.
• W2047908311 cites W1577224607 @default.
• W2047908311 cites W1581090091 @default.
• W2047908311 cites W1589015352 @default.
• W2047908311 cites W1595416591 @default.
• W2047908311 cites W1620990221 @default.
• W2047908311 cites W1681127287 @default.
• W2047908311 cites W1741639066 @default.
• W2047908311 cites W1864733621 @default.
• W2047908311 cites W1930502921 @default.
• W2047908311 cites W1963486398 @default.
• W2047908311 cites W1964315599 @default.
• W2047908311 cites W1964597276 @default.
• W2047908311 cites W1966013501 @default.
• W2047908311 cites W1967825074 @default.
• W2047908311 cites W1967963412 @default.
• W2047908311 cites W1969104605 @default.
• W2047908311 cites W1970312798 @default.
• W2047908311 cites W1971015814 @default.
• W2047908311 cites W1971532261 @default.
• W2047908311 cites W1971665655 @default.
• W2047908311 cites W1972732038 @default.
• W2047908311 cites W1972810033 @default.
• W2047908311 cites W1973557149 @default.
• W2047908311 cites W1973986558 @default.
• W2047908311 cites W1974948524 @default.
• W2047908311 cites W1976435108 @default.
• W2047908311 cites W1976579720 @default.
• W2047908311 cites W1976707885 @default.
• W2047908311 cites W1977180011 @default.
• W2047908311 cites W1977568892 @default.
• W2047908311 cites W1979636612 @default.
• W2047908311 cites W1981452763 @default.
• W2047908311 cites W1983471115 @default.
• W2047908311 cites W1985109518 @default.
• W2047908311 cites W1987111435 @default.
• W2047908311 cites W1988892631 @default.
• W2047908311 cites W1989692357 @default.
• W2047908311 cites W1989767424 @default.
• W2047908311 cites W1994672969 @default.
• W2047908311 cites W1995364413 @default.
• W2047908311 cites W1996800910 @default.
• W2047908311 cites W1996810774 @default.
• W2047908311 cites W1997395738 @default.
• W2047908311 cites W1997932302 @default.
• W2047908311 cites W1998379369 @default.
• W2047908311 cites W1998703496 @default.
• W2047908311 cites W1999959617 @default.
• W2047908311 cites W2000244695 @default.
• W2047908311 cites W2001004078 @default.
• W2047908311 cites W2001828472 @default.
• W2047908311 cites W2002947389 @default.
• W2047908311 cites W2003750313 @default.
• W2047908311 cites W2006875003 @default.
• W2047908311 cites W2007218685 @default.
• W2047908311 cites W2008079372 @default.
• W2047908311 cites W2008606615 @default.
• W2047908311 cites W2010465686 @default.
• W2047908311 cites W2010684683 @default.
• W2047908311 cites W2010936746 @default.
• W2047908311 cites W2010987335 @default.
• W2047908311 cites W2011426662 @default.
• W2047908311 cites W2011973003 @default.
• W2047908311 cites W2012255717 @default.
• W2047908311 cites W2014370769 @default.
• W2047908311 cites W2015740286 @default.
• W2047908311 cites W2016309667 @default.
• W2047908311 cites W2016321438 @default.
• W2047908311 cites W2017227716 @default.
• W2047908311 cites W2017716389 @default.
• W2047908311 cites W2018373327 @default.
• W2047908311 cites W2019791978 @default.
• W2047908311 cites W2020040226 @default.
• W2047908311 cites W2020392235 @default.
• W2047908311 cites W2021194790 @default.
• W2047908311 cites W2024344189 @default.
• W2047908311 cites W2025939332 @default.
• W2047908311 cites W2026413318 @default.
• W2047908311 cites W2027642061 @default.
• W2047908311 cites W2028264287 @default.
• W2047908311 cites W2029032935 @default.
• W2047908311 cites W2029559183 @default.
• W2047908311 cites W2030158939 @default.

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