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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047929348> ?p ?o ?g. }

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• W2047929348 abstract "The MAPK/ERK signalling pathway has been described to mediate IL-1 induction of target genes and is known to be regulated by microRNAs (miRNA). We describe a novel miRNA regulating the expression of the MEK1 gene and how it impacts IL-1 induced IL-6 transcription. miR-497 was predicted to target MEK1 3'UTR using bioinformatic tools. Transfection of miR-497 into HeLa cells inhibited MEK1 protein expression by 50%. In transient transfection experiments, the luciferase activity of a MEK1 3'UTR luciferase reporter construct was reduced in the presence of miR-497, and mutation of the predicted miR-497 binding site restored activity. miR-497 also decreased protein levels of RAF1 and ERK1 but not ERK2. Addition of miR-497 was further shown to inhibit IL-1 induced IL-6 gene transcription." @default.
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• W2047929348 creator A5053246999 @default.
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• W2047929348 date "2012-10-22" @default.
• W2047929348 modified "2023-09-26" @default.
• W2047929348 title "MicroRNA 497 modulates interleukin 1 signalling via the MAPK/ERK pathway" @default.
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• W2047929348 doi "https://doi.org/10.1016/j.febslet.2012.10.014" @default.
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