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- W2047954003 abstract "<h2>Abstract</h2> We have investigated the effects of 2,3-DPG on platelet aggregation in the presence of suboptimal concentrations of Na-Arachidonate by using the two cuvette transfer experiments of Hamberg, Svensson and Samuelsson (3). The results show that 2,3-DPG enhanced or induced platelet aggregation in the presence of suboptimal concentrations of Na-Arachidonate. Imidazole, a TXA<sub>2</sub> synthetase inhibitor, and Lasix, when added inhibited 2,3-DPG effects on platelet aggregation, suggesting that 2,3-DPG may act either on cyclooxygenase or on TXA<sub>2</sub> synthetase of prostaglandin synthesis. A specific RIA assay showed that 2,3-DPG when added to suboptimal concentrations of Na-Arachidonate enhanced the formation of TXB<sub>2</sub>, a stable metabolite of TXA<sub>2</sub>. We have concluded that during intravascular hemolysis 2,3-DPG release may be a key component in preventing and/or inducing thrombosis." @default.
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- W2047954003 date "1986-04-01" @default.
- W2047954003 modified "2023-10-14" @default.
- W2047954003 title "The combined effects of 2,3-DPG and Na-arachidonate on platelet aggregation and on TXA2 formation" @default.
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- W2047954003 doi "https://doi.org/10.1016/0049-3848(86)90293-8" @default.
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