FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047981010> ?p ?o ?g. }

• W2047981010 endingPage "312.e2" @default.
• W2047981010 startingPage "305" @default.
• W2047981010 abstract "ObjectiveLosartan potassium (INN losartan), an antihypertensive drug, has been shown to prevent thoracic aortic aneurysm in Marfan syndrome through the inhibition of transforming growth factor β. Recently we reported that doxycycline, a nonspecific inhibitor of matrix metalloproteinases 2 and 9, normalized aortic vasomotor function and suppressed aneurysm growth. We hypothesized that a combination of losartan potassium and doxycycline would offer better secondary prevention treatment than would single-drug therapy to manage thoracic aortic aneurysm.MethodsA well-characterized mouse model of Marfan syndrome (Fbn1C1039G/+) was used. At 4 months of age, when aneurysm had established, mice (n = 15/group) were given doxycycline alone (0.24 g/L), losartan potassium alone (0.6 g/L), or combined (0.12-g/L doxycycline and 0.3-g/L losartan potassium) in drinking water. Littermate Fbn1+/+ mice served as control. Thoracic aortas at 6 and 9 months were studied.ResultsAt 9 months, aortic diameter in untreated group was increased by 40% relative to control. Losartan potassium or doxycycline reduced aortic diameter by 10% to 16% versus untreated aortas. Losartan potassium and doxycycline combined completely prevented thoracic aortic aneurysm and improved elastic fiber organization, also downregulating matrix metalloproteinases 2 and 9 and transforming growth factor β and normalizing aortic contractile and relaxation functions to control values.ConclusionsNeither losartan potassium nor doxycycline alone completely restored vascular integrity and cell function when given during delayed treatment, indicating the importance of timed pharmacologic intervention. Combined, however, they synergistically offered better aneurysm-suppressing effects than did single-drug medication in the secondary prevention of thoracic aortic aneurysm. Losartan potassium (INN losartan), an antihypertensive drug, has been shown to prevent thoracic aortic aneurysm in Marfan syndrome through the inhibition of transforming growth factor β. Recently we reported that doxycycline, a nonspecific inhibitor of matrix metalloproteinases 2 and 9, normalized aortic vasomotor function and suppressed aneurysm growth. We hypothesized that a combination of losartan potassium and doxycycline would offer better secondary prevention treatment than would single-drug therapy to manage thoracic aortic aneurysm. A well-characterized mouse model of Marfan syndrome (Fbn1C1039G/+) was used. At 4 months of age, when aneurysm had established, mice (n = 15/group) were given doxycycline alone (0.24 g/L), losartan potassium alone (0.6 g/L), or combined (0.12-g/L doxycycline and 0.3-g/L losartan potassium) in drinking water. Littermate Fbn1+/+ mice served as control. Thoracic aortas at 6 and 9 months were studied. At 9 months, aortic diameter in untreated group was increased by 40% relative to control. Losartan potassium or doxycycline reduced aortic diameter by 10% to 16% versus untreated aortas. Losartan potassium and doxycycline combined completely prevented thoracic aortic aneurysm and improved elastic fiber organization, also downregulating matrix metalloproteinases 2 and 9 and transforming growth factor β and normalizing aortic contractile and relaxation functions to control values. Neither losartan potassium nor doxycycline alone completely restored vascular integrity and cell function when given during delayed treatment, indicating the importance of timed pharmacologic intervention. Combined, however, they synergistically offered better aneurysm-suppressing effects than did single-drug medication in the secondary prevention of thoracic aortic aneurysm." @default.
• W2047981010 created "2016-06-24" @default.
• W2047981010 creator A5002300605 @default.
• W2047981010 creator A5010950726 @default.
• W2047981010 creator A5019198824 @default.
• W2047981010 creator A5040791199 @default.
• W2047981010 creator A5040901061 @default.
• W2047981010 date "2010-08-01" @default.
• W2047981010 modified "2023-10-18" @default.
• W2047981010 title "Effectiveness of combination of losartan potassium and doxycycline versus single-drug treatments in the secondary prevention of thoracic aortic aneurysm in Marfan syndrome" @default.
• W2047981010 cites W1535702312 @default.
• W2047981010 cites W1977824141 @default.
• W2047981010 cites W1983007537 @default.
• W2047981010 cites W1991998151 @default.
• W2047981010 cites W2002953524 @default.
• W2047981010 cites W2014726507 @default.
• W2047981010 cites W2021827924 @default.
• W2047981010 cites W2036505292 @default.
• W2047981010 cites W2036733178 @default.
• W2047981010 cites W2058832901 @default.
• W2047981010 cites W2067456305 @default.
• W2047981010 cites W2070599153 @default.
• W2047981010 cites W2075221458 @default.
• W2047981010 cites W2099447852 @default.
• W2047981010 cites W2100637998 @default.
• W2047981010 cites W2105430887 @default.
• W2047981010 cites W2106181496 @default.
• W2047981010 cites W2113836385 @default.
• W2047981010 cites W2122588714 @default.
• W2047981010 cites W2127451461 @default.
• W2047981010 cites W2131202416 @default.
• W2047981010 cites W2132925844 @default.
• W2047981010 cites W2151046779 @default.
• W2047981010 cites W2152350731 @default.
• W2047981010 cites W2157357973 @default.
• W2047981010 cites W2165892440 @default.
• W2047981010 cites W2317397529 @default.
• W2047981010 doi "https://doi.org/10.1016/j.jtcvs.2009.10.039" @default.
• W2047981010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20189193" @default.
• W2047981010 hasPublicationYear "2010" @default.
• W2047981010 type Work @default.
• W2047981010 sameAs 2047981010 @default.
• W2047981010 citedByCount "71" @default.
• W2047981010 countsByYear W20479810102012 @default.
• W2047981010 countsByYear W20479810102013 @default.
• W2047981010 countsByYear W20479810102014 @default.
• W2047981010 countsByYear W20479810102015 @default.
• W2047981010 countsByYear W20479810102016 @default.
• W2047981010 countsByYear W20479810102017 @default.
• W2047981010 countsByYear W20479810102018 @default.
• W2047981010 countsByYear W20479810102019 @default.
• W2047981010 countsByYear W20479810102020 @default.
• W2047981010 countsByYear W20479810102021 @default.
• W2047981010 countsByYear W20479810102022 @default.
• W2047981010 countsByYear W20479810102023 @default.
• W2047981010 crossrefType "journal-article" @default.
• W2047981010 hasAuthorship W2047981010A5002300605 @default.
• W2047981010 hasAuthorship W2047981010A5010950726 @default.
• W2047981010 hasAuthorship W2047981010A5019198824 @default.
• W2047981010 hasAuthorship W2047981010A5040791199 @default.
• W2047981010 hasAuthorship W2047981010A5040901061 @default.
• W2047981010 hasBestOaLocation W20479810101 @default.
• W2047981010 hasConcept C126322002 @default.
• W2047981010 hasConcept C126894567 @default.
• W2047981010 hasConcept C141071460 @default.
• W2047981010 hasConcept C164705383 @default.
• W2047981010 hasConcept C2776098176 @default.
• W2047981010 hasConcept C2776864027 @default.
• W2047981010 hasConcept C2777179404 @default.
• W2047981010 hasConcept C2777323849 @default.
• W2047981010 hasConcept C2779980429 @default.
• W2047981010 hasConcept C2780288358 @default.
• W2047981010 hasConcept C2780561598 @default.
• W2047981010 hasConcept C2780847584 @default.
• W2047981010 hasConcept C2908929049 @default.
• W2047981010 hasConcept C2909209853 @default.
• W2047981010 hasConcept C501593827 @default.
• W2047981010 hasConcept C71924100 @default.
• W2047981010 hasConcept C84393581 @default.
• W2047981010 hasConcept C86803240 @default.
• W2047981010 hasConcept C89423630 @default.
• W2047981010 hasConcept C98274493 @default.
• W2047981010 hasConceptScore W2047981010C126322002 @default.
• W2047981010 hasConceptScore W2047981010C126894567 @default.
• W2047981010 hasConceptScore W2047981010C141071460 @default.
• W2047981010 hasConceptScore W2047981010C164705383 @default.
• W2047981010 hasConceptScore W2047981010C2776098176 @default.
• W2047981010 hasConceptScore W2047981010C2776864027 @default.
• W2047981010 hasConceptScore W2047981010C2777179404 @default.
• W2047981010 hasConceptScore W2047981010C2777323849 @default.
• W2047981010 hasConceptScore W2047981010C2779980429 @default.
• W2047981010 hasConceptScore W2047981010C2780288358 @default.
• W2047981010 hasConceptScore W2047981010C2780561598 @default.
• W2047981010 hasConceptScore W2047981010C2780847584 @default.
• W2047981010 hasConceptScore W2047981010C2908929049 @default.
• W2047981010 hasConceptScore W2047981010C2909209853 @default.
• W2047981010 hasConceptScore W2047981010C501593827 @default.
• W2047981010 hasConceptScore W2047981010C71924100 @default.

• next