FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047995004> ?p ?o ?g. }

• W2047995004 endingPage "e1003985" @default.
• W2047995004 startingPage "e1003985" @default.
• W2047995004 abstract "The replication of many RNA viruses involves the translation of polyproteins, whose processing by endopeptidases is a critical step for the release of functional subunits. P1 is the first protease encoded in plant potyvirus genomes; once activated by an as-yet-unknown host factor, it acts in cis on its own C-terminal end, hydrolyzing the P1-HCPro junction. Earlier research suggests that P1 cooperates with HCPro to inhibit host RNA silencing defenses. Using Plum pox virus as a model, we show that although P1 does not have a major direct role in RNA silencing suppression, it can indeed modulate HCPro function by its self-cleavage activity. To study P1 protease regulation, we used bioinformatic analysis and in vitro activity experiments to map the core C-terminal catalytic domain. We present evidence that the hypervariable region that precedes the protease domain is predicted as intrinsically disordered, and that it behaves as a negative regulator of P1 proteolytic activity in in vitro cleavage assays. In viral infections, removal of the P1 protease antagonistic regulator is associated with greater symptom severity, induction of salicylate-dependent pathogenesis-related proteins, and reduced viral loads. We suggest that fine modulation of a viral protease activity has evolved to keep viral amplification below host-detrimental levels, and thus to maintain higher long-term replicative capacity." @default.
• W2047995004 created "2016-06-24" @default.
• W2047995004 creator A5018342150 @default.
• W2047995004 creator A5051426072 @default.
• W2047995004 creator A5084492619 @default.
• W2047995004 date "2014-03-06" @default.
• W2047995004 modified "2023-10-14" @default.
• W2047995004 title "The Hypervariable Amino-Terminus of P1 Protease Modulates Potyviral Replication and Host Defense Responses" @default.
• W2047995004 cites W1480753383 @default.
• W2047995004 cites W1487649776 @default.
• W2047995004 cites W1496069534 @default.
• W2047995004 cites W1560210520 @default.
• W2047995004 cites W1963616587 @default.
• W2047995004 cites W1965155039 @default.
• W2047995004 cites W1968474579 @default.
• W2047995004 cites W1968687512 @default.
• W2047995004 cites W1969336544 @default.
• W2047995004 cites W1971439989 @default.
• W2047995004 cites W1971508902 @default.
• W2047995004 cites W1973354049 @default.
• W2047995004 cites W1974585984 @default.
• W2047995004 cites W1975085160 @default.
• W2047995004 cites W1975643266 @default.
• W2047995004 cites W1978832369 @default.
• W2047995004 cites W1979965542 @default.
• W2047995004 cites W1986508375 @default.
• W2047995004 cites W1987235162 @default.
• W2047995004 cites W1988346702 @default.
• W2047995004 cites W1992074806 @default.
• W2047995004 cites W1992360162 @default.
• W2047995004 cites W1993179336 @default.
• W2047995004 cites W1994123538 @default.
• W2047995004 cites W1995104031 @default.
• W2047995004 cites W1997303954 @default.
• W2047995004 cites W2000711592 @default.
• W2047995004 cites W2002900330 @default.
• W2047995004 cites W2009393104 @default.
• W2047995004 cites W2010626519 @default.
• W2047995004 cites W2014483325 @default.
• W2047995004 cites W2024556021 @default.
• W2047995004 cites W2027341070 @default.
• W2047995004 cites W2039445936 @default.
• W2047995004 cites W2046886534 @default.
• W2047995004 cites W2047640436 @default.
• W2047995004 cites W2051666884 @default.
• W2047995004 cites W2052062968 @default.
• W2047995004 cites W2053850578 @default.
• W2047995004 cites W2056643642 @default.
• W2047995004 cites W2057132428 @default.
• W2047995004 cites W2061710160 @default.
• W2047995004 cites W2061954020 @default.
• W2047995004 cites W2063776548 @default.
• W2047995004 cites W2064749048 @default.
• W2047995004 cites W2065832641 @default.
• W2047995004 cites W2071504725 @default.
• W2047995004 cites W2074876040 @default.
• W2047995004 cites W2077376180 @default.
• W2047995004 cites W2078063954 @default.
• W2047995004 cites W2079486904 @default.
• W2047995004 cites W2080285022 @default.
• W2047995004 cites W2080929480 @default.
• W2047995004 cites W2082027575 @default.
• W2047995004 cites W2082909190 @default.
• W2047995004 cites W2083699890 @default.
• W2047995004 cites W2084035056 @default.
• W2047995004 cites W2089031128 @default.
• W2047995004 cites W2092053018 @default.
• W2047995004 cites W2095328130 @default.
• W2047995004 cites W2096495474 @default.
• W2047995004 cites W2097828379 @default.
• W2047995004 cites W2098998842 @default.
• W2047995004 cites W2099540110 @default.
• W2047995004 cites W2100376874 @default.
• W2047995004 cites W2107536885 @default.
• W2047995004 cites W2107542943 @default.
• W2047995004 cites W2108007518 @default.
• W2047995004 cites W2108931188 @default.
• W2047995004 cites W2110573616 @default.
• W2047995004 cites W2111796823 @default.
• W2047995004 cites W2115034937 @default.
• W2047995004 cites W2115877842 @default.
• W2047995004 cites W2115882842 @default.
• W2047995004 cites W2118236489 @default.
• W2047995004 cites W2120016245 @default.
• W2047995004 cites W2120772351 @default.
• W2047995004 cites W2125345424 @default.
• W2047995004 cites W2126064524 @default.
• W2047995004 cites W2132926880 @default.
• W2047995004 cites W2133874630 @default.
• W2047995004 cites W2135078307 @default.
• W2047995004 cites W2138540004 @default.
• W2047995004 cites W2139582206 @default.
• W2047995004 cites W2140990045 @default.
• W2047995004 cites W2143430694 @default.
• W2047995004 cites W2149165580 @default.
• W2047995004 cites W2149283088 @default.
• W2047995004 cites W2149499236 @default.
• W2047995004 cites W2149993527 @default.

• next