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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048005189> ?p ?o ?g. }

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• W2048005189 abstract "Several N(1)-substituted 1,3-dihydro-2H-benzimidazol-2-ones were synthesized and evaluated as anti-HIV agents. Some of them proved to be highly effective in inhibiting HIV-1 replication at nanomolar concentration as potent non-nucleoside HIV-1 RT inhibitors (NNRTIs) with low cytotoxicity. SAR studies highlighted that the nature of the substituents at N(1) and on the benzene ring of benzimidazolone moiety significantly influenced the anti-HIV activity of this class of potent antiretroviral agents." @default.
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• W2048005189 date "2008-08-01" @default.
• W2048005189 modified "2023-09-25" @default.
• W2048005189 title "Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors" @default.
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• W2048005189 doi "https://doi.org/10.1016/j.bmc.2008.06.012" @default.
• W2048005189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18585918" @default.
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