Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048005240> ?p ?o ?g. }
- W2048005240 endingPage "497" @default.
- W2048005240 startingPage "491" @default.
- W2048005240 abstract "The activation of phospholipase D in different cell lines treated with recombinant human tumor necrosis factor (TNF) has been investigated. When the murine fibrosarcoma cell lines L929 and WEHI164c113, as well as the human promonocytic cell line U937, were prelabeled with [14C]palmitic acid or [3H]arachidonic acid, and treated with TNF in the presence of ethanol, TNF induced the synthesis of [14C]phosphatidylethanol or [3H]phosphatidylethanol, respectively, as the result of a phospholipase-D-catalyzed transphosphatidylation. TNF-induced phospholipase D activity was observed 1 h before the onset of cell killing and gradually increased thereafter. Subclones selected for resistance to TNF cytotoxicity did not show phospholipase D activation in response to TNF. In contrast, when these subclones were treated with TNF in the presence of actinomycin D, TNF cytotoxicity as well as TNF-induced phospholipase D activity could be restored. TNF cytotoxicity and TNF-induced phospholipase D activity were equally modulated by various drugs known to interfere with different steps in the TNF-signaling pathway. Phospholipase D activation was found not to be the result of cell killing per se, as a number of other cytotoxic reagents were unable to activate phospholipase D. Prelabeling of cells with [14C]lysophosphatidylcholine indicated phosphatidylcholine as one of the substrates for TNF-activated phospholipase D. In conclusion, this study demonstrates that TNF-induced cytotoxicity is associated with activation of phospholipase D." @default.
- W2048005240 created "2016-06-24" @default.
- W2048005240 creator A5035047337 @default.
- W2048005240 creator A5053142767 @default.
- W2048005240 creator A5080918885 @default.
- W2048005240 creator A5083518782 @default.
- W2048005240 date "1993-03-01" @default.
- W2048005240 modified "2023-09-26" @default.
- W2048005240 title "Tumor necrosis factor cytotoxicity is associated with phospholipase D activation" @default.
- W2048005240 cites W1245295209 @default.
- W2048005240 cites W1481451080 @default.
- W2048005240 cites W1493283928 @default.
- W2048005240 cites W1493531388 @default.
- W2048005240 cites W1512600725 @default.
- W2048005240 cites W1518259698 @default.
- W2048005240 cites W1534995893 @default.
- W2048005240 cites W1539809249 @default.
- W2048005240 cites W1549527149 @default.
- W2048005240 cites W1560104562 @default.
- W2048005240 cites W1598875012 @default.
- W2048005240 cites W1603439931 @default.
- W2048005240 cites W1607723356 @default.
- W2048005240 cites W1973580269 @default.
- W2048005240 cites W1976384164 @default.
- W2048005240 cites W2025092789 @default.
- W2048005240 cites W2031882933 @default.
- W2048005240 cites W2034593795 @default.
- W2048005240 cites W2041165390 @default.
- W2048005240 cites W2043127339 @default.
- W2048005240 cites W2046489172 @default.
- W2048005240 cites W2047688511 @default.
- W2048005240 cites W2055090334 @default.
- W2048005240 cites W2064035247 @default.
- W2048005240 cites W2074218975 @default.
- W2048005240 cites W2078317160 @default.
- W2048005240 cites W2078609121 @default.
- W2048005240 cites W2079090986 @default.
- W2048005240 cites W2084897022 @default.
- W2048005240 cites W2094003696 @default.
- W2048005240 cites W2102431039 @default.
- W2048005240 cites W2127012055 @default.
- W2048005240 cites W2132915524 @default.
- W2048005240 cites W2134246272 @default.
- W2048005240 cites W2152311269 @default.
- W2048005240 cites W2159401430 @default.
- W2048005240 cites W2162465275 @default.
- W2048005240 cites W2162656609 @default.
- W2048005240 cites W22156987 @default.
- W2048005240 cites W2266717059 @default.
- W2048005240 cites W2332744955 @default.
- W2048005240 doi "https://doi.org/10.1111/j.1432-1033.1993.tb17686.x" @default.
- W2048005240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8444187" @default.
- W2048005240 hasPublicationYear "1993" @default.
- W2048005240 type Work @default.
- W2048005240 sameAs 2048005240 @default.
- W2048005240 citedByCount "30" @default.
- W2048005240 countsByYear W20480052402014 @default.
- W2048005240 countsByYear W20480052402019 @default.
- W2048005240 crossrefType "journal-article" @default.
- W2048005240 hasAuthorship W2048005240A5035047337 @default.
- W2048005240 hasAuthorship W2048005240A5053142767 @default.
- W2048005240 hasAuthorship W2048005240A5080918885 @default.
- W2048005240 hasAuthorship W2048005240A5083518782 @default.
- W2048005240 hasConcept C109316439 @default.
- W2048005240 hasConcept C12927208 @default.
- W2048005240 hasConcept C134018914 @default.
- W2048005240 hasConcept C153911025 @default.
- W2048005240 hasConcept C17991360 @default.
- W2048005240 hasConcept C181199279 @default.
- W2048005240 hasConcept C185592680 @default.
- W2048005240 hasConcept C202751555 @default.
- W2048005240 hasConcept C2776330855 @default.
- W2048005240 hasConcept C2776551241 @default.
- W2048005240 hasConcept C2778078955 @default.
- W2048005240 hasConcept C2778597717 @default.
- W2048005240 hasConcept C2778918659 @default.
- W2048005240 hasConcept C2780202252 @default.
- W2048005240 hasConcept C41625074 @default.
- W2048005240 hasConcept C54355233 @default.
- W2048005240 hasConcept C55493867 @default.
- W2048005240 hasConcept C6182249 @default.
- W2048005240 hasConcept C62478195 @default.
- W2048005240 hasConcept C81885089 @default.
- W2048005240 hasConcept C86803240 @default.
- W2048005240 hasConceptScore W2048005240C109316439 @default.
- W2048005240 hasConceptScore W2048005240C12927208 @default.
- W2048005240 hasConceptScore W2048005240C134018914 @default.
- W2048005240 hasConceptScore W2048005240C153911025 @default.
- W2048005240 hasConceptScore W2048005240C17991360 @default.
- W2048005240 hasConceptScore W2048005240C181199279 @default.
- W2048005240 hasConceptScore W2048005240C185592680 @default.
- W2048005240 hasConceptScore W2048005240C202751555 @default.
- W2048005240 hasConceptScore W2048005240C2776330855 @default.
- W2048005240 hasConceptScore W2048005240C2776551241 @default.
- W2048005240 hasConceptScore W2048005240C2778078955 @default.
- W2048005240 hasConceptScore W2048005240C2778597717 @default.
- W2048005240 hasConceptScore W2048005240C2778918659 @default.
- W2048005240 hasConceptScore W2048005240C2780202252 @default.