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- W2048008180 abstract "The presence of hydroxyurea (HU) during G2 potentiated the yield of chromatid-type aberrations induced by X-rays and Streptonigrin in human lymphocytes. A potentiating effect of the same type and magnitude was obtained, when caffeine was given as a post-treatment during G2. It was further demonstrated that the X-ray-induced mitotic delay was shortened by caffeine and prolonged by HU. The results indicate that there is a process for repair of DNA damage late in G2 and that chromatid aberrations may be produced when this repair process fails or makes mistakes. Both caffeine and HU are believed to reduce the efficiency of the repair process; caffeine by shortening the time available for repair and HU by reducing the supply of material required for repair." @default.
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- W2048008180 date "2008-06-28" @default.
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- W2048008180 title "Potentiation of X-ray and Streptonigrin-induced chromosomal aberrations in human lymphocytes by post-treatments with hydroxyurea and caffeine" @default.
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- W2048008180 doi "https://doi.org/10.1111/j.1601-5223.1982.tb00711.x" @default.
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