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• W2048016663 startingPage "127" @default.
• W2048016663 abstract "Hepatitis C virus (HCV) commonly causes a chronic infection, but a minority of patients are able to clear the virus and do not run the risk of developing HCV-induced organ damage. Genetic associations between immunoregulatory cytokines interleukin (IL)-1, -6, and -10 with clinical features of HCV, including virus clearance, have been inconsistent. We determined cytokine genotypes in 606 patients who had serologic evidence of HCV exposure, 190 (18%) of whom were consistently negative for HCV RNA, indicating successful virus clearance. There was no significant difference in genotype frequencies between HCV clearance and nonclearance groups for IL-1B (-511 and +3954), IL-1A (+4845), IL-1RN (+2018), IL-6 (-174), or IL-10 (-1082). We conclude that these single nucleotide polymorphisms are unlikely to play an important, if any, role in determining the likelihood of clearing HCV infection." @default.
• W2048016663 created "2016-06-24" @default.
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• W2048016663 date "2005-02-01" @default.
• W2048016663 modified "2023-09-27" @default.
• W2048016663 title "Clearance of hepatitis C virus is not associated with single nucleotide polymorphisms in the IL-1, -6, or -10 genes" @default.
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• W2048016663 doi "https://doi.org/10.1016/j.humimm.2004.11.001" @default.
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• W2048016663 hasPublicationYear "2005" @default.
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