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• W2048025753 abstract "In order to characterize neuropeptide Y (NPY) receptors present in human adipocytes, we used selective ligands together with specific molecular probes able to recognize the different NPY receptor subtypes. RT‐PCR experiments revealed the presence of Y 1 receptor transcripts with Y 4 and Y 5 and absence of Y 2 signals. Binding studies, using selective radioiodinated ligands, detected a high number ( B max =497±124 fmol/mg protein) of a high affinity binding site only with [ 125 I]peptide YY (PYY) and [ 125 I](Leu 31 ,Pro 34 )PYY. These sites exhibited a typical Y 1 profile as indicated by the rank order of affinity of NPY analogs and the high affinity of two selective NPY receptor antagonists, SR120819A and BIBP3226. In [ 35 S]GTPγS binding experiments, PYY activation was totally inhibited by SR120819A and BIBP3226. Both compounds antagonized, with similar efficiency, the antilipolytic effect exerted by NPY in isolated adipocytes. Finally, PYY and Y 1 ligands enhanced adipocyte leptin secretion, an effect totally prevented by SR120819A. Thus, highly expressed in human adipocytes, the Y 1 receptor sustains the strong antilipolytic effect of NPY and exerts a positive action on leptin secretion." @default.
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• W2048025753 date "2000-06-15" @default.
• W2048025753 modified "2023-10-18" @default.
• W2048025753 title "Characterization of NPY receptors controlling lipolysis and leptin secretion in human adipocytes" @default.
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• W2048025753 doi "https://doi.org/10.1016/s0014-5793(00)01649-5" @default.
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