FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048034747> ?p ?o ?g. }

• W2048034747 endingPage "293" @default.
• W2048034747 startingPage "282" @default.
• W2048034747 abstract "We examined if the relative expression of JNK-interacting protein 1 (JIP1) and phosphorylated c-Jun N-terminal kinase (JNK) regulates cell signaling and contributes to selective neuronal vulnerability in response to environmental stress. In clonal neuroblastoma cultures, stresses such as hypoxia, ischemia, Abeta peptides, and UV irradiation rapidly reduced JIP1 expression. JIP1 mRNA expression was also down-regulated by UV stress and was accompanied by increased JNK and c-Jun activation and cell death. JIP1 protein reduction was partially reversed both by inhibitors predominantly of caspase 3 and of the JNK pathway and resulted in significantly increased cell survival. Conversely, overexpression of JIP1 decreased both nuclear translocation of activated-JNK, and c-Jun phosphorylation induced by either UV irradiation, or the JNK upstream activators, MKK7 or MEKK1. Cell death was reduced about 50% compared to GFP-transfected controls. JIP1 overexpression did not facilitate either JNK expression or activation. In the normal, non-stressed human hippocampus and rat hippocampal organotypic cultures, JIP1 and JNK3 were inversely expressed with more JIP1 in CA2 and CA3 and less in CA1 neurons. In the human hippocampus, transient hypoxia/ischemia selectively spares neurons in CA2 and CA3 and induces death of neurons in the hippocampal CA1 subregion. In the cultures, ischemia reduced JIP1 expression and activated JNK, c-Jun, and caspase 3. Inhibitors of the JNK pathway, JNK activation directly and of caspase 3 activation each partially reversed these effects. Thus, under certain stress conditions, down-regulation of JIP1 expression makes neurons more susceptible to apoptosis, suggesting JIP may serve as an anti-apoptosis factor." @default.
• W2048034747 created "2016-06-24" @default.
• W2048034747 creator A5004141488 @default.
• W2048034747 creator A5036188969 @default.
• W2048034747 creator A5039906789 @default.
• W2048034747 creator A5076463487 @default.
• W2048034747 creator A5077660361 @default.
• W2048034747 creator A5078384785 @default.
• W2048034747 date "2005-04-01" @default.
• W2048034747 modified "2023-10-01" @default.
• W2048034747 title "JIP1 regulates neuronal apoptosis in response to stress" @default.
• W2048034747 cites W1486333767 @default.
• W2048034747 cites W1495983806 @default.
• W2048034747 cites W1515821225 @default.
• W2048034747 cites W1549081254 @default.
• W2048034747 cites W1572174728 @default.
• W2048034747 cites W1816379352 @default.
• W2048034747 cites W1860048316 @default.
• W2048034747 cites W1899552864 @default.
• W2048034747 cites W1945304257 @default.
• W2048034747 cites W1967218150 @default.
• W2048034747 cites W1971676222 @default.
• W2048034747 cites W1973227020 @default.
• W2048034747 cites W1973914231 @default.
• W2048034747 cites W1976385326 @default.
• W2048034747 cites W1976519846 @default.
• W2048034747 cites W1983420534 @default.
• W2048034747 cites W1992068984 @default.
• W2048034747 cites W1993351141 @default.
• W2048034747 cites W2003805549 @default.
• W2048034747 cites W2005969483 @default.
• W2048034747 cites W2011185477 @default.
• W2048034747 cites W2012571494 @default.
• W2048034747 cites W2021653518 @default.
• W2048034747 cites W2022232747 @default.
• W2048034747 cites W2022762164 @default.
• W2048034747 cites W2022840078 @default.
• W2048034747 cites W2025999056 @default.
• W2048034747 cites W2027323074 @default.
• W2048034747 cites W2036426920 @default.
• W2048034747 cites W2043635727 @default.
• W2048034747 cites W2045929031 @default.
• W2048034747 cites W2047604959 @default.
• W2048034747 cites W2051448083 @default.
• W2048034747 cites W2067213521 @default.
• W2048034747 cites W2068814836 @default.
• W2048034747 cites W2073637588 @default.
• W2048034747 cites W2076485183 @default.
• W2048034747 cites W2079054696 @default.
• W2048034747 cites W2085499348 @default.
• W2048034747 cites W2087073346 @default.
• W2048034747 cites W2093674448 @default.
• W2048034747 cites W2094155854 @default.
• W2048034747 cites W2096931514 @default.
• W2048034747 cites W2101704246 @default.
• W2048034747 cites W2108036214 @default.
• W2048034747 cites W2119807130 @default.
• W2048034747 cites W2128994713 @default.
• W2048034747 cites W2136232340 @default.
• W2048034747 cites W2139488506 @default.
• W2048034747 cites W2147103035 @default.
• W2048034747 cites W2149789552 @default.
• W2048034747 cites W2155483393 @default.
• W2048034747 cites W2160038308 @default.
• W2048034747 cites W2160076767 @default.
• W2048034747 cites W2304943976 @default.
• W2048034747 doi "https://doi.org/10.1016/j.molbrainres.2004.10.039" @default.
• W2048034747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15836924" @default.
• W2048034747 hasPublicationYear "2005" @default.
• W2048034747 type Work @default.
• W2048034747 sameAs 2048034747 @default.
• W2048034747 citedByCount "27" @default.
• W2048034747 countsByYear W20480347472012 @default.
• W2048034747 countsByYear W20480347472014 @default.
• W2048034747 countsByYear W20480347472015 @default.
• W2048034747 countsByYear W20480347472017 @default.
• W2048034747 countsByYear W20480347472018 @default.
• W2048034747 countsByYear W20480347472019 @default.
• W2048034747 countsByYear W20480347472020 @default.
• W2048034747 countsByYear W20480347472021 @default.
• W2048034747 countsByYear W20480347472022 @default.
• W2048034747 countsByYear W20480347472023 @default.
• W2048034747 crossrefType "journal-article" @default.
• W2048034747 hasAuthorship W2048034747A5004141488 @default.
• W2048034747 hasAuthorship W2048034747A5036188969 @default.
• W2048034747 hasAuthorship W2048034747A5039906789 @default.
• W2048034747 hasAuthorship W2048034747A5076463487 @default.
• W2048034747 hasAuthorship W2048034747A5077660361 @default.
• W2048034747 hasAuthorship W2048034747A5078384785 @default.
• W2048034747 hasConcept C104317684 @default.
• W2048034747 hasConcept C11960822 @default.
• W2048034747 hasConcept C126322002 @default.
• W2048034747 hasConcept C134018914 @default.
• W2048034747 hasConcept C148762608 @default.
• W2048034747 hasConcept C153911025 @default.
• W2048034747 hasConcept C184235292 @default.
• W2048034747 hasConcept C190283241 @default.
• W2048034747 hasConcept C2779087070 @default.

• next