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- W2048042151 abstract "Les patients porteurs d’un cancer bronchique non à petites cellules (CBNPC) avancé, en mauvais état général sont souvent peu représentés dans les essais cliniques. Ceci entraîne une définition souvent empirique de leur prise en charge. Plusieurs travaux récents démontrent l’intérêt de la chimiothérapie chez les patients de PS (performance status) 2, qui améliore à la fois les symptômes et probablement la survie. En revanche, il persiste un débat sur l’intérêt d’une monothérapie ou d’une bithérapie dans ce groupe de patients. Les inhibiteurs de tyrosine kinase de l’EGFR ont démontré leur intérêt chez les patients prétraités, apportant à la fois un bénéfice clinique et un bénéfice de survie dans des études randomisées qui ont inclus un nombre significatif de patients en mauvais état général. Patients with poor performance status (PS) and advanced lung cancer have been underrepresented in clinical trials. As a consequence, the management of these patients in clinical practice is often empirical. Recent data indicate that patients with advanced non-small cell lung cancer (NSCLC) and a PS of 2 tend to benefit from first line chemotherapy with respect to symptom improvement and perhaps overall survival. Whether single-agent or combination chemotherapy is preferable remains debatable. In previously treated patients with NSCLC, EGFR tyrosine kinase inhibitors produced a substantial rate of clinical benefit and led to an improvement in survival compared with placebo in studies that included a significant percentage of patients with poor PS." @default.
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- W2048042151 date "2007-10-01" @default.
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- W2048042151 title "Quel traitement pour un patient de PS-2/3 ayant un cancer bronchique non à petites cellules (CBNPC)" @default.
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- W2048042151 doi "https://doi.org/10.1016/s0761-8425(07)78144-5" @default.
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