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- W2048045157 endingPage "e1001043" @default.
- W2048045157 startingPage "e1001043" @default.
- W2048045157 abstract "The pathogenesis of persistent infection is dictated by the balance between opposing immune activation and suppression signals. Herein, virulent Salmonella was used to explore the role and potential importance of Foxp3-expressing regulatory T cells in dictating the natural progression of persistent bacterial infection. Two distinct phases of persistent Salmonella infection are identified. In the first 3–4 weeks after infection, progressively increasing bacterial burden was associated with delayed effector T cell activation. Reciprocally, at later time points after infection, reductions in bacterial burden were associated with robust effector T cell activation. Using Foxp3GFP reporter mice for ex vivo isolation of regulatory T cells, we demonstrate that the dichotomy in infection tempo between early and late time points is directly paralleled by drastic changes in Foxp3+ Treg suppressive potency. In complementary experiments using Foxp3DTR mice, the significance of these shifts in Treg suppressive potency on infection outcome was verified by enumerating the relative impacts of regulatory T cell ablation on bacterial burden and effector T cell activation at early and late time points during persistent Salmonella infection. Moreover, Treg expression of CTLA-4 directly paralleled changes in suppressive potency, and the relative effects of Treg ablation could be largely recapitulated by CTLA-4 in vivo blockade. Together, these results demonstrate that dynamic regulation of Treg suppressive potency dictates the course of persistent bacterial infection." @default.
- W2048045157 created "2016-06-24" @default.
- W2048045157 creator A5009227577 @default.
- W2048045157 creator A5067439715 @default.
- W2048045157 creator A5077751908 @default.
- W2048045157 creator A5085490923 @default.
- W2048045157 date "2010-08-12" @default.
- W2048045157 modified "2023-09-27" @default.
- W2048045157 title "Regulatory T Cell Suppressive Potency Dictates the Balance between Bacterial Proliferation and Clearance during Persistent Salmonella Infection" @default.
- W2048045157 cites W1489852543 @default.
- W2048045157 cites W1497240165 @default.
- W2048045157 cites W1525978917 @default.
- W2048045157 cites W1566416470 @default.
- W2048045157 cites W1588272261 @default.
- W2048045157 cites W1591644715 @default.
- W2048045157 cites W1744462629 @default.
- W2048045157 cites W1847048918 @default.
- W2048045157 cites W1895843741 @default.
- W2048045157 cites W1935040042 @default.
- W2048045157 cites W1947143056 @default.
- W2048045157 cites W1950159513 @default.
- W2048045157 cites W1960197119 @default.
- W2048045157 cites W1988102816 @default.
- W2048045157 cites W1996984101 @default.
- W2048045157 cites W1998603634 @default.
- W2048045157 cites W2000587047 @default.
- W2048045157 cites W2001740313 @default.
- W2048045157 cites W2003602243 @default.
- W2048045157 cites W2009112167 @default.
- W2048045157 cites W2016551156 @default.
- W2048045157 cites W2018308106 @default.
- W2048045157 cites W2021603971 @default.
- W2048045157 cites W2023038954 @default.
- W2048045157 cites W2023659884 @default.
- W2048045157 cites W2026426963 @default.
- W2048045157 cites W2026810672 @default.
- W2048045157 cites W2033415145 @default.
- W2048045157 cites W2034917555 @default.
- W2048045157 cites W2036117709 @default.
- W2048045157 cites W2039808886 @default.
- W2048045157 cites W2046941247 @default.
- W2048045157 cites W2049449911 @default.
- W2048045157 cites W2058112140 @default.
- W2048045157 cites W2061071534 @default.
- W2048045157 cites W2066933577 @default.
- W2048045157 cites W2066951766 @default.
- W2048045157 cites W2067648924 @default.
- W2048045157 cites W2070443202 @default.
- W2048045157 cites W2080612883 @default.
- W2048045157 cites W2082224040 @default.
- W2048045157 cites W2084128540 @default.
- W2048045157 cites W2091483766 @default.
- W2048045157 cites W2097509788 @default.
- W2048045157 cites W2097811455 @default.
- W2048045157 cites W2099291451 @default.
- W2048045157 cites W2100357356 @default.
- W2048045157 cites W2100827722 @default.
- W2048045157 cites W2101230909 @default.
- W2048045157 cites W2105450674 @default.
- W2048045157 cites W2105484520 @default.
- W2048045157 cites W2106190040 @default.
- W2048045157 cites W2108064918 @default.
- W2048045157 cites W2108690268 @default.
- W2048045157 cites W2110753254 @default.
- W2048045157 cites W2116082836 @default.
- W2048045157 cites W2116666774 @default.
- W2048045157 cites W2119275893 @default.
- W2048045157 cites W2121835123 @default.
- W2048045157 cites W2123761806 @default.
- W2048045157 cites W2124621398 @default.
- W2048045157 cites W2126072190 @default.
- W2048045157 cites W2130440599 @default.
- W2048045157 cites W2130486201 @default.
- W2048045157 cites W2132427916 @default.
- W2048045157 cites W2133972276 @default.
- W2048045157 cites W2135623402 @default.
- W2048045157 cites W2136305342 @default.
- W2048045157 cites W2136369541 @default.
- W2048045157 cites W2139627888 @default.
- W2048045157 cites W2142657250 @default.
- W2048045157 cites W2143286868 @default.
- W2048045157 cites W2143660954 @default.
- W2048045157 cites W2147858215 @default.
- W2048045157 cites W2149915530 @default.
- W2048045157 cites W2153389047 @default.
- W2048045157 cites W2154261733 @default.
- W2048045157 cites W2154975285 @default.
- W2048045157 cites W2158602538 @default.
- W2048045157 cites W2159987448 @default.
- W2048045157 cites W2160670021 @default.
- W2048045157 cites W2160927866 @default.
- W2048045157 cites W2161545566 @default.
- W2048045157 cites W2167897159 @default.
- W2048045157 cites W4251041657 @default.
- W2048045157 cites W4254002014 @default.
- W2048045157 doi "https://doi.org/10.1371/journal.ppat.1001043" @default.
- W2048045157 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2920851" @default.
- W2048045157 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20714351" @default.