FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048049479> ?p ?o ?g. }

• W2048049479 endingPage "166" @default.
• W2048049479 startingPage "159" @default.
• W2048049479 abstract "Volume stability and growth of tissue engineered adipose tissue equivalents using adipose-derived stem cells (ASCs) rely strongly on angiogenesis and neovascularization to support the maintenance of cells. An attractive cellular approach is based on coimplantation of endothelial cells to create a vascular network. Endothelial progenitor cells (EPCs) are a promising cell population, since they can be easily isolated from autologous human peripheral blood and thus represent a clinically feasible option. We have previously shown in in vitro and semi-in vivo studies that ASCs exert beneficial effects on EPCs in terms of enhanced tube formation and formation of blood vessels, respectively. In this study, we investigated the in vivo effects of coimplantation on endothelial cell-mediated neovascularization and ASC-mediated adipose tissue formation. For this purpose, human ASCs and human EPCs (or HUVECs as direct comparison to EPCs) were suspended alone or in coculture in fibrin and subcutaneously injected into the back of athymic nude mice and explanted after 1, 3 or 6 months. Our results show that monocultures of EPCs or HUVECs were not able to perform vasculogenesis and constructs exhibited complete resorption already after 1 month. However, a remarkable difference between EPCs and HUVECs was detected when coimplanted with ASCs. While coimplanted HUVECs gave rise to a stable neovasculature which was characterized by perfusion with erythrocytes, coimplanted EPCs showed no ability to form vascular structures. In the case of HUVEC-derived neovasculature, coimplanted ASCs displayed perivascular properties by stabilizing these neovessels. However, formation of human adipose tissue was independent of coimplanted endothelial cells. Our results indicate that HUVECs are superior to EPCs in terms of promoting in vivo neovascularization and recruiting perivascular cells for vessel stabilization when coimplanted with ASCs." @default.
• W2048049479 created "2016-06-24" @default.
• W2048049479 creator A5042609923 @default.
• W2048049479 creator A5068685918 @default.
• W2048049479 creator A5069124349 @default.
• W2048049479 creator A5070303634 @default.
• W2048049479 creator A5083371787 @default.
• W2048049479 date "2015-01-01" @default.
• W2048049479 modified "2023-09-27" @default.
• W2048049479 title "Comparison between endothelial progenitor cells and human umbilical vein endothelial cells on neovascularization in an adipogenesis mouse model" @default.
• W2048049479 cites W1567686711 @default.
• W2048049479 cites W1605777639 @default.
• W2048049479 cites W1971481846 @default.
• W2048049479 cites W1971850571 @default.
• W2048049479 cites W1975111290 @default.
• W2048049479 cites W1975292043 @default.
• W2048049479 cites W1977345428 @default.
• W2048049479 cites W1982321458 @default.
• W2048049479 cites W1983444416 @default.
• W2048049479 cites W1987602947 @default.
• W2048049479 cites W1990800923 @default.
• W2048049479 cites W1998502869 @default.
• W2048049479 cites W1999326999 @default.
• W2048049479 cites W2004611121 @default.
• W2048049479 cites W2005794950 @default.
• W2048049479 cites W2006961900 @default.
• W2048049479 cites W2011979365 @default.
• W2048049479 cites W2016775082 @default.
• W2048049479 cites W2021634519 @default.
• W2048049479 cites W2029782351 @default.
• W2048049479 cites W2031462636 @default.
• W2048049479 cites W2034433473 @default.
• W2048049479 cites W2039092880 @default.
• W2048049479 cites W2041925658 @default.
• W2048049479 cites W2051989707 @default.
• W2048049479 cites W2052846669 @default.
• W2048049479 cites W2063666536 @default.
• W2048049479 cites W2072939681 @default.
• W2048049479 cites W2074395402 @default.
• W2048049479 cites W2089004231 @default.
• W2048049479 cites W2090264742 @default.
• W2048049479 cites W2091440761 @default.
• W2048049479 cites W2096599017 @default.
• W2048049479 cites W2107800413 @default.
• W2048049479 cites W2136089486 @default.
• W2048049479 cites W2139534935 @default.
• W2048049479 cites W2139716106 @default.
• W2048049479 cites W2151142958 @default.
• W2048049479 cites W2152442991 @default.
• W2048049479 cites W2168215545 @default.
• W2048049479 cites W2170250170 @default.
• W2048049479 cites W2173497140 @default.
• W2048049479 cites W2176082399 @default.
• W2048049479 cites W2176853075 @default.
• W2048049479 cites W2322264561 @default.
• W2048049479 doi "https://doi.org/10.1016/j.mvr.2014.10.005" @default.
• W2048049479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25446371" @default.
• W2048049479 hasPublicationYear "2015" @default.
• W2048049479 type Work @default.
• W2048049479 sameAs 2048049479 @default.
• W2048049479 citedByCount "27" @default.
• W2048049479 countsByYear W20480494792015 @default.
• W2048049479 countsByYear W20480494792016 @default.
• W2048049479 countsByYear W20480494792017 @default.
• W2048049479 countsByYear W20480494792018 @default.
• W2048049479 countsByYear W20480494792019 @default.
• W2048049479 countsByYear W20480494792020 @default.
• W2048049479 countsByYear W20480494792021 @default.
• W2048049479 countsByYear W20480494792022 @default.
• W2048049479 countsByYear W20480494792023 @default.
• W2048049479 crossrefType "journal-article" @default.
• W2048049479 hasAuthorship W2048049479A5042609923 @default.
• W2048049479 hasAuthorship W2048049479A5068685918 @default.
• W2048049479 hasAuthorship W2048049479A5069124349 @default.
• W2048049479 hasAuthorship W2048049479A5070303634 @default.
• W2048049479 hasAuthorship W2048049479A5083371787 @default.
• W2048049479 hasConcept C122927707 @default.
• W2048049479 hasConcept C123012128 @default.
• W2048049479 hasConcept C134018914 @default.
• W2048049479 hasConcept C171089720 @default.
• W2048049479 hasConcept C201750760 @default.
• W2048049479 hasConcept C202751555 @default.
• W2048049479 hasConcept C2777411675 @default.
• W2048049479 hasConcept C2778271429 @default.
• W2048049479 hasConcept C2780152582 @default.
• W2048049479 hasConcept C2780394083 @default.
• W2048049479 hasConcept C28328180 @default.
• W2048049479 hasConcept C2908647359 @default.
• W2048049479 hasConcept C502942594 @default.
• W2048049479 hasConcept C55493867 @default.
• W2048049479 hasConcept C60781801 @default.
• W2048049479 hasConcept C71924100 @default.
• W2048049479 hasConcept C86803240 @default.
• W2048049479 hasConcept C95444343 @default.
• W2048049479 hasConcept C99454951 @default.
• W2048049479 hasConceptScore W2048049479C122927707 @default.
• W2048049479 hasConceptScore W2048049479C123012128 @default.
• W2048049479 hasConceptScore W2048049479C134018914 @default.

• next