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• W2048049888 abstract "From the fruiting bodies of the mushroom Lyophyllum shimeji, a novel ribosome inactivating protein with a molecular weight of 20 kDa and exhibiting antifungal activity against Physalospora piricola (IC(50) = 2.5 microM) and Coprinus comatus was isolated. The protein, designated lyophyllin, was purified by ion exchange chromatography on CM-cellulose, affinity chromatography on Affi-gel Blue Gel, and then ion exchange chromatography on Mono S. Lyophyllin possessed an N-terminal sequence with some similarity to those of plant ribosome-inactivating proteins. It inhibited translation in rabbit reticulocyte lysate with an IC(50) of 1 nM, thymidine uptake by murine splenocytes with an IC(50) of 1 microM and HIV-1 reverse transcriptase activity with an IC(50) of 7.9 nM. Lyophyllin did not manifest ribonuclease or hemagglutinating activity. An antifungal protein, designated Lyophyllum antifungal protein (LAP), with a molecular weight of 14 kDa, and an N-terminal sequence somewhat analogous to those of angiosperm thaumatin-like proteins and thaumatins and an inactive variant of the ubiquitin-conjugating enzyme, was first isolated from Lyophyllum shimeji. LAP was adsorbed on CM-cellulose, Affi-gel blue gel, and Mono S. LAP exerted antifungal activity against P. piricola (IC(50) = 70 nM) and Mycosphaerella arachidicola but not against Rhizoctonia solani, Colletotrichum gossypii, and Coprinus comatus. It exerted very low translation inhibitory activity in a rabbit reticulocyte lysate system (IC(50) = 70 microM) and negligible ribonuclease activity toward yeast transfer RNA and hemagglutinating activity toward rabbit erythrocytes. It inhibited HIV-1 reverse transcriptase with an IC(50) of about 5.2 nM. A synergism in antifungal activities of LAP and lyophyllin against P. piricola was demonstrable." @default.
• W2048049888 created "2016-06-24" @default.
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• W2048049888 date "2001-09-01" @default.
• W2048049888 modified "2023-10-13" @default.
• W2048049888 title "First Simultaneous Isolation of a Ribosome Inactivating Protein and an Antifungal Protein from a Mushroom (Lyophyllum shimeji) Together with Evidence for Synergism of their Antifungal Effects" @default.
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• W2048049888 doi "https://doi.org/10.1006/abbi.2001.2506" @default.
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