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- W2048058234 abstract "Recent advances in single-molecule imaging in living cells allow quantitative and system-wide descriptions of gene expression and regulation with single molecule sensitivity. It was found that low probability events of single molecules can have important biological consequences, such as the change of a cellular phenotype. This has everything to do with the fact that DNA are single molecules in individual cells. Meanwhile, recent advances in high throughput DNA sequencing and whole genome and transcriptome amplification have allowed sequencing the genome and transcriptome of a single human cell. The combination of single-molecule imaging and sequencing in single cells offers exciting possibilities for understanding dynamics in living systems." @default.
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- W2048058234 date "2013-01-01" @default.
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- W2048058234 title "Imaging and Sequencing Single Molecules in Individual Cells" @default.
- W2048058234 doi "https://doi.org/10.1016/j.bpj.2012.11.2148" @default.
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