FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048063669> ?p ?o ?g. }

• W2048063669 endingPage "230" @default.
• W2048063669 startingPage "222" @default.
• W2048063669 abstract "The morbidity and lethality of tuberculosis is partially the result of an ineffective delayed-type hypersensitivity reaction which causes caseating granulomas in the lung and other organs. Recently we showed that during caseation besides macrophages numerous Fas+ FasL+ lymphocytes undergo apoptosis and postulated that this phenomenon may be due to activation-induced cell death (AICD) as a consequence of T-lymphocyte reactivation via bacillary antigens. As purified protein derivative of Mycobacterium tuberculosis (Mtb-PPD) provokes caseation in tuberculosis patients, the question arose as to whether bacillary antigens are responsible for AICD within caseous areas. In the present study Mtb-PPD-specific T helper 1 (Th1)-differentiated T lymphocytes were generated in vitro. Reactivation of these cells with Mtb-PPD resulted in a concentration-dependent hyporesponsiveness, which was due to an increase in apoptosis of γδ+, αβ+ CD4+ as well as αβ+ CD8+ T lymphocytes as assessed by the demonstration of the apoptosis-associated mitochondrial membrane protein 7A6 and DNA fragmentation. Blocking experiments demonstrated that Mtb-PPD antigens exploited the Fas/FasL system to induce apoptosis in Mtb-PPD-specific T lymphocytes. These results may support the hypothesis that in tubercle granulomas with caseation T lymphocytes undergo AICD following reactivation by bacillary antigens, thus contributing to the persistence of tuberculosis." @default.
• W2048063669 created "2016-06-24" @default.
• W2048063669 creator A5021187964 @default.
• W2048063669 creator A5054869317 @default.
• W2048063669 creator A5082506567 @default.
• W2048063669 creator A5089291064 @default.
• W2048063669 date "2002-02-01" @default.
• W2048063669 modified "2023-09-26" @default.
• W2048063669 title "Mycobacterial antigens induce apoptosis in human purified protein derivative-specific alphabeta T lymphocytes in a concentration-dependent manner" @default.
• W2048063669 cites W1528876949 @default.
• W2048063669 cites W1536595294 @default.
• W2048063669 cites W1608787955 @default.
• W2048063669 cites W1661544713 @default.
• W2048063669 cites W1922883684 @default.
• W2048063669 cites W1961207913 @default.
• W2048063669 cites W1972922050 @default.
• W2048063669 cites W1985523738 @default.
• W2048063669 cites W1986779497 @default.
• W2048063669 cites W1989134194 @default.
• W2048063669 cites W1998377021 @default.
• W2048063669 cites W2003285575 @default.
• W2048063669 cites W2003416799 @default.
• W2048063669 cites W2004826057 @default.
• W2048063669 cites W2007692917 @default.
• W2048063669 cites W2013304854 @default.
• W2048063669 cites W2016336432 @default.
• W2048063669 cites W2017484317 @default.
• W2048063669 cites W2023809975 @default.
• W2048063669 cites W2027981004 @default.
• W2048063669 cites W2029599607 @default.
• W2048063669 cites W2033940262 @default.
• W2048063669 cites W2041070177 @default.
• W2048063669 cites W2041179613 @default.
• W2048063669 cites W2041678990 @default.
• W2048063669 cites W2044163622 @default.
• W2048063669 cites W2057617426 @default.
• W2048063669 cites W2059214352 @default.
• W2048063669 cites W2073078847 @default.
• W2048063669 cites W2085159985 @default.
• W2048063669 cites W2088901514 @default.
• W2048063669 cites W2092034926 @default.
• W2048063669 cites W2097106158 @default.
• W2048063669 cites W2097106414 @default.
• W2048063669 cites W2097231057 @default.
• W2048063669 cites W21005853 @default.
• W2048063669 cites W2104106789 @default.
• W2048063669 cites W2107491761 @default.
• W2048063669 cites W2117193299 @default.
• W2048063669 cites W2121472628 @default.
• W2048063669 cites W2129971278 @default.
• W2048063669 cites W2131761283 @default.
• W2048063669 cites W2139535814 @default.
• W2048063669 cites W2144350275 @default.
• W2048063669 cites W2164734343 @default.
• W2048063669 cites W2166243539 @default.
• W2048063669 cites W2170450192 @default.
• W2048063669 cites W2207631321 @default.
• W2048063669 cites W2322322464 @default.
• W2048063669 cites W2415916058 @default.
• W2048063669 cites W2824123905 @default.
• W2048063669 cites W2942530663 @default.
• W2048063669 cites W4242587786 @default.
• W2048063669 cites W4313333863 @default.
• W2048063669 cites W4313422348 @default.
• W2048063669 doi "https://doi.org/10.1046/j.0019-2805.2001.01355.x" @default.
• W2048063669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1782647" @default.
• W2048063669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11872098" @default.
• W2048063669 hasPublicationYear "2002" @default.
• W2048063669 type Work @default.
• W2048063669 sameAs 2048063669 @default.
• W2048063669 citedByCount "13" @default.
• W2048063669 countsByYear W20480636692013 @default.
• W2048063669 countsByYear W20480636692014 @default.
• W2048063669 countsByYear W20480636692015 @default.
• W2048063669 countsByYear W20480636692016 @default.
• W2048063669 countsByYear W20480636692017 @default.
• W2048063669 countsByYear W20480636692022 @default.
• W2048063669 countsByYear W20480636692023 @default.
• W2048063669 crossrefType "journal-article" @default.
• W2048063669 hasAuthorship W2048063669A5021187964 @default.
• W2048063669 hasAuthorship W2048063669A5054869317 @default.
• W2048063669 hasAuthorship W2048063669A5082506567 @default.
• W2048063669 hasAuthorship W2048063669A5089291064 @default.
• W2048063669 hasBestOaLocation W20480636692 @default.
• W2048063669 hasConcept C142724271 @default.
• W2048063669 hasConcept C147483822 @default.
• W2048063669 hasConcept C167672396 @default.
• W2048063669 hasConcept C190283241 @default.
• W2048063669 hasConcept C203014093 @default.
• W2048063669 hasConcept C2777975735 @default.
• W2048063669 hasConcept C2781069245 @default.
• W2048063669 hasConcept C2992881475 @default.
• W2048063669 hasConcept C31573885 @default.
• W2048063669 hasConcept C55493867 @default.
• W2048063669 hasConcept C66008609 @default.
• W2048063669 hasConcept C71924100 @default.
• W2048063669 hasConcept C86803240 @default.
• W2048063669 hasConceptScore W2048063669C142724271 @default.

• next