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- W2048082168 abstract "The β-receptor blocking actions of ICI 50172 were compared with those of propranolol, pronethalol and MJ 1999. It antagonized the cardiac effects but did not affect the depressor action of isoprenaline in the anaesthetized cat. The dose-effect curve for ICI 50172 was flatter than for the other antagonists. Autonomic reflexes did not account for the difference in curves. ICI 50172 antagonized the actions of isoprenaline on guinea-pig bronchi, rabbit intestine and rat uterus. It had one seventh to one threehundredth the potency of propranolol in these respects. It had anti-arrhythmic activity in cats in which ventricular tachycardia was produced by methylchloroform and adrenaline. ICI 50172 had β-receptor agonistic actions on heart, bronchi, intestine and uterus, particularly in high doses; thus, it differed from the usual pattern for partial agonists. Possible explanations for it" @default.
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- W2048082168 title "The effects of ICI 50172, propranolol, pronethalol and MJ 1999 on β-receptors" @default.
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- W2048082168 doi "https://doi.org/10.1016/0014-2999(69)90125-3" @default.
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