FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048083523> ?p ?o ?g. }

• W2048083523 endingPage "681" @default.
• W2048083523 startingPage "669" @default.
• W2048083523 abstract "Immune cell trafficking is crucial for surveillance and effector functions of the immune system. Circadian rhythms of the hypothalamic-pituitary-adrenal (HPA) axis and of cortisol have been implicated in circadian redistribution of circulating lymphocytes and granulocytes. However, information regarding the diurnal redistribution of immune cells and their temporal correlations with cortisol is scarce. In this study, we investigated the diurnal redistribution of T, B, and natural killer (NK) cell subsets in relation to the endogenous cortisol rhythm. Saliva and blood samples were collected every 15 min over an 8-h period. Salivary-free cortisol was measured by enzyme-linked immunosorbent assay (ELISA). Surface markers (CD3, CD19, CD8, CD56, CD16, KIR) were measured in whole blood samples by 6-color flow cytometry and cell subsets quantified as a percentage of the total lymphocyte population. To study associations between the diurnal cortisol rhythm and the redistribution of T, B, and NK cells, we calculated cross-correlations with lag periods of 15 min. The salivary cortisol levels showed the typical diurnal variations with a significant morning cortisol awakening response (CAR) peaking around 07:30 h followed by an afternoon nadir. Whereas B cells remained stable throughout the 8 h, T cells (CD3 + CD8+ and CD3 + CD8−) showed a significant positive cross-correlation with cortisol levels when a delay of 30–105 min was taken into account. This was followed by a negative correlation covering a period of 165–285 min after the cortisol peak. Conversely, NK cells showed an initial negative correlation at 45–105 min, followed by a positive correlation at 120–285 min. The major CD56 + CD16+ subset and the CD56 − CD16+ population showed similar temporal correlation profiles. The minor CD56 + CD16− NK cell subset showed no temporal changes. The major NK subset (CD56 + CD16+) contains cells with higher cytolytic activity (KIR+) cells, whereas the single-positive subsets CD56 + CD16− and CD56 − CD16+ are mainly involved in cytokine production. Significant positive correlations were observed in KIR+ subsets coincident with this of NK cells covering a period of 105–300 min after the cortisol peak. In conclusion, our results suggest that cortisol and the HPA axis orchestrate tidal waves of immune cells that are alternatively based toward innate and acquired immune surveillance. (Author correspondence: claude.muller@CRP-SANTE.LU)" @default.
• W2048083523 created "2016-06-24" @default.
• W2048083523 creator A5020556533 @default.
• W2048083523 creator A5037088216 @default.
• W2048083523 creator A5045079036 @default.
• W2048083523 creator A5084914497 @default.
• W2048083523 date "2013-05-20" @default.
• W2048083523 modified "2023-09-27" @default.
• W2048083523 title "Diurnal redistribution of human lymphocytes and their temporal associations with salivary cortisol" @default.
• W2048083523 cites W1584483067 @default.
• W2048083523 cites W1823110493 @default.
• W2048083523 cites W1964681740 @default.
• W2048083523 cites W1969814796 @default.
• W2048083523 cites W1974521853 @default.
• W2048083523 cites W1977047809 @default.
• W2048083523 cites W1984537429 @default.
• W2048083523 cites W1989561452 @default.
• W2048083523 cites W1990754840 @default.
• W2048083523 cites W1991279493 @default.
• W2048083523 cites W1992094377 @default.
• W2048083523 cites W2004181758 @default.
• W2048083523 cites W2018254460 @default.
• W2048083523 cites W2033147224 @default.
• W2048083523 cites W2054146939 @default.
• W2048083523 cites W2062781189 @default.
• W2048083523 cites W2075194189 @default.
• W2048083523 cites W2076803535 @default.
• W2048083523 cites W2119573232 @default.
• W2048083523 cites W2158378430 @default.
• W2048083523 cites W2160536056 @default.
• W2048083523 cites W2162554428 @default.
• W2048083523 cites W2327067203 @default.
• W2048083523 doi "https://doi.org/10.3109/07420528.2013.775654" @default.
• W2048083523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23688120" @default.
• W2048083523 hasPublicationYear "2013" @default.
• W2048083523 type Work @default.
• W2048083523 sameAs 2048083523 @default.
• W2048083523 citedByCount "15" @default.
• W2048083523 countsByYear W20480835232013 @default.
• W2048083523 countsByYear W20480835232014 @default.
• W2048083523 countsByYear W20480835232015 @default.
• W2048083523 countsByYear W20480835232016 @default.
• W2048083523 countsByYear W20480835232017 @default.
• W2048083523 countsByYear W20480835232018 @default.
• W2048083523 countsByYear W20480835232019 @default.
• W2048083523 countsByYear W20480835232020 @default.
• W2048083523 countsByYear W20480835232021 @default.
• W2048083523 countsByYear W20480835232022 @default.
• W2048083523 countsByYear W20480835232023 @default.
• W2048083523 crossrefType "journal-article" @default.
• W2048083523 hasAuthorship W2048083523A5020556533 @default.
• W2048083523 hasAuthorship W2048083523A5037088216 @default.
• W2048083523 hasAuthorship W2048083523A5045079036 @default.
• W2048083523 hasAuthorship W2048083523A5084914497 @default.
• W2048083523 hasConcept C121446783 @default.
• W2048083523 hasConcept C126322002 @default.
• W2048083523 hasConcept C134018914 @default.
• W2048083523 hasConcept C167672396 @default.
• W2048083523 hasConcept C19720800 @default.
• W2048083523 hasConcept C203014093 @default.
• W2048083523 hasConcept C2777761686 @default.
• W2048083523 hasConcept C2778709874 @default.
• W2048083523 hasConcept C2908647359 @default.
• W2048083523 hasConcept C504460877 @default.
• W2048083523 hasConcept C71924100 @default.
• W2048083523 hasConcept C86803240 @default.
• W2048083523 hasConcept C8891405 @default.
• W2048083523 hasConcept C99454951 @default.
• W2048083523 hasConceptScore W2048083523C121446783 @default.
• W2048083523 hasConceptScore W2048083523C126322002 @default.
• W2048083523 hasConceptScore W2048083523C134018914 @default.
• W2048083523 hasConceptScore W2048083523C167672396 @default.
• W2048083523 hasConceptScore W2048083523C19720800 @default.
• W2048083523 hasConceptScore W2048083523C203014093 @default.
• W2048083523 hasConceptScore W2048083523C2777761686 @default.
• W2048083523 hasConceptScore W2048083523C2778709874 @default.
• W2048083523 hasConceptScore W2048083523C2908647359 @default.
• W2048083523 hasConceptScore W2048083523C504460877 @default.
• W2048083523 hasConceptScore W2048083523C71924100 @default.
• W2048083523 hasConceptScore W2048083523C86803240 @default.
• W2048083523 hasConceptScore W2048083523C8891405 @default.
• W2048083523 hasConceptScore W2048083523C99454951 @default.
• W2048083523 hasIssue "5" @default.
• W2048083523 hasLocation W20480835231 @default.
• W2048083523 hasLocation W20480835232 @default.
• W2048083523 hasOpenAccess W2048083523 @default.
• W2048083523 hasPrimaryLocation W20480835231 @default.
• W2048083523 hasRelatedWork W1983217032 @default.
• W2048083523 hasRelatedWork W1986673839 @default.
• W2048083523 hasRelatedWork W1997915932 @default.
• W2048083523 hasRelatedWork W2007649676 @default.
• W2048083523 hasRelatedWork W2059593117 @default.
• W2048083523 hasRelatedWork W2082409955 @default.
• W2048083523 hasRelatedWork W2092341993 @default.
• W2048083523 hasRelatedWork W2101550646 @default.
• W2048083523 hasRelatedWork W2117909172 @default.
• W2048083523 hasRelatedWork W4253599722 @default.
• W2048083523 hasVolume "30" @default.

• next