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- W2048091716 abstract "The administration of L-asparaginase causes regression of certain lymphoid tumours in rodents, suggesting that the enzyme may inhibit the activity of normal lymphoid cells and thus have an immunosuppressive effect. The effect of L-asparaginase treatment in mice on the survival of skin allografts and on the antibody response to i.p. injected sheep red blood cells was studied. In both experimental situations, the degree of response to the antigenie challenge was reduced. A single dose of asparaginase was effective when given at the same time as the sheep red blood cells and up to 48 hr afterward. The enzyme was unable to diminish the response to a second injection of sheep red blood cells in previously stimulated mice." @default.
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- W2048091716 date "1970-06-01" @default.
- W2048091716 modified "2023-10-18" @default.
- W2048091716 title "IMMUNOSUPPRESSIVE ACTIVITY OF L-ASPARAGINASE IN MICE" @default.
- W2048091716 doi "https://doi.org/10.1097/00007890-197006000-00005" @default.
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