FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048099756> ?p ?o ?g. }

• W2048099756 endingPage "1479" @default.
• W2048099756 startingPage "1469" @default.
• W2048099756 abstract "Collagenase-1 (MMP-1) is a protease that is expressed by stromal cells and that is involved in remodeling of the extracellular matrix. IL-1 and TNF-alpha enhance collagenase secretion by stromal cells, and chronic exposure of cells to these cytokines can contribute to connective tissue disease. In this study, we show that the NF-kappaB pathway is required for activation of collagenase-1 transcription in rabbit primary synovial fibroblasts (RSF). Although both IL-1 and TNF activate NF-kappaB in these cells, only IL-1 induces collagenase-1 transcription. We have reported previously that NF-kappaB and AP-1 cooperate to mediate IL-1-induced MMP-1 transcription. Here, we show that IL-1 is superior to TNF at inducing c-Jun synthesis, phosphorylation and binding activity in RSF. Similarly, IL-1 is more effective at activating the mitogen-activated protein kinases (MAPK), including the extracellular signal-regulated kinases (ERK), which are required for IL-1-induced MMP-1 transcription. Thus stimulation of the ERK and AP-1 pathways is an essential component of MMP-1 transcriptional activation, which is deficient in TNF-treated cells. These studies demonstrate cooperation between the MAPK and NF-kappaB signaling pathways for IL-1-dependent collagenase-1 transcription, and they define a dichotomy of IL-1- and TNF-elicited signaling that is relevant to cytokine-mediated connective tissue disease." @default.
• W2048099756 created "2016-06-24" @default.
• W2048099756 creator A5037217342 @default.
• W2048099756 creator A5041655739 @default.
• W2048099756 creator A5070208304 @default.
• W2048099756 date "2000-10-01" @default.
• W2048099756 modified "2023-10-16" @default.
• W2048099756 title "Integration of the NF-κB and mitogen-activated protein kinase/AP-1 pathways at the Collagenase-1 promoter: Divergence of IL-1 and TNF-dependent signal transduction in rabbit primary synovial fibroblasts" @default.
• W2048099756 cites W1572174728 @default.
• W2048099756 cites W1660988713 @default.
• W2048099756 cites W1662189542 @default.
• W2048099756 cites W1915074145 @default.
• W2048099756 cites W1964201687 @default.
• W2048099756 cites W1967004332 @default.
• W2048099756 cites W1968376159 @default.
• W2048099756 cites W1977302628 @default.
• W2048099756 cites W1983729225 @default.
• W2048099756 cites W1984903682 @default.
• W2048099756 cites W1986010238 @default.
• W2048099756 cites W1995168933 @default.
• W2048099756 cites W1998549662 @default.
• W2048099756 cites W2002282120 @default.
• W2048099756 cites W2003411699 @default.
• W2048099756 cites W2005389617 @default.
• W2048099756 cites W2005402970 @default.
• W2048099756 cites W2007986629 @default.
• W2048099756 cites W2016730049 @default.
• W2048099756 cites W2028501194 @default.
• W2048099756 cites W2031670584 @default.
• W2048099756 cites W2035936653 @default.
• W2048099756 cites W2040703859 @default.
• W2048099756 cites W2042289154 @default.
• W2048099756 cites W2045973968 @default.
• W2048099756 cites W2053372168 @default.
• W2048099756 cites W2063646307 @default.
• W2048099756 cites W2068823402 @default.
• W2048099756 cites W2073579223 @default.
• W2048099756 cites W2079607078 @default.
• W2048099756 cites W2090871210 @default.
• W2048099756 cites W2099729324 @default.
• W2048099756 cites W2106457973 @default.
• W2048099756 cites W2110911902 @default.
• W2048099756 cites W2113190937 @default.
• W2048099756 cites W2118897660 @default.
• W2048099756 cites W2145828270 @default.
• W2048099756 cites W2147678437 @default.
• W2048099756 cites W2150905382 @default.
• W2048099756 cites W2159891151 @default.
• W2048099756 cites W2162821604 @default.
• W2048099756 cites W2167031471 @default.
• W2048099756 cites W3120153401 @default.
• W2048099756 cites W4313376959 @default.
• W2048099756 doi "https://doi.org/10.1006/cyto.2000.0743" @default.
• W2048099756 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11023661" @default.
• W2048099756 hasPublicationYear "2000" @default.
• W2048099756 type Work @default.
• W2048099756 sameAs 2048099756 @default.
• W2048099756 citedByCount "147" @default.
• W2048099756 countsByYear W20480997562012 @default.
• W2048099756 countsByYear W20480997562013 @default.
• W2048099756 countsByYear W20480997562014 @default.
• W2048099756 countsByYear W20480997562015 @default.
• W2048099756 countsByYear W20480997562016 @default.
• W2048099756 countsByYear W20480997562017 @default.
• W2048099756 countsByYear W20480997562018 @default.
• W2048099756 countsByYear W20480997562019 @default.
• W2048099756 countsByYear W20480997562020 @default.
• W2048099756 countsByYear W20480997562021 @default.
• W2048099756 countsByYear W20480997562022 @default.
• W2048099756 countsByYear W20480997562023 @default.
• W2048099756 crossrefType "journal-article" @default.
• W2048099756 hasAuthorship W2048099756A5037217342 @default.
• W2048099756 hasAuthorship W2048099756A5041655739 @default.
• W2048099756 hasAuthorship W2048099756A5070208304 @default.
• W2048099756 hasConcept C153911025 @default.
• W2048099756 hasConcept C16930146 @default.
• W2048099756 hasConcept C181199279 @default.
• W2048099756 hasConcept C184235292 @default.
• W2048099756 hasConcept C185592680 @default.
• W2048099756 hasConcept C2778394429 @default.
• W2048099756 hasConcept C502942594 @default.
• W2048099756 hasConcept C55493867 @default.
• W2048099756 hasConcept C57074206 @default.
• W2048099756 hasConcept C62478195 @default.
• W2048099756 hasConcept C86803240 @default.
• W2048099756 hasConcept C95444343 @default.
• W2048099756 hasConcept C97029542 @default.
• W2048099756 hasConceptScore W2048099756C153911025 @default.
• W2048099756 hasConceptScore W2048099756C16930146 @default.
• W2048099756 hasConceptScore W2048099756C181199279 @default.
• W2048099756 hasConceptScore W2048099756C184235292 @default.
• W2048099756 hasConceptScore W2048099756C185592680 @default.
• W2048099756 hasConceptScore W2048099756C2778394429 @default.
• W2048099756 hasConceptScore W2048099756C502942594 @default.
• W2048099756 hasConceptScore W2048099756C55493867 @default.
• W2048099756 hasConceptScore W2048099756C57074206 @default.
• W2048099756 hasConceptScore W2048099756C62478195 @default.
• W2048099756 hasConceptScore W2048099756C86803240 @default.

• next