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• W2048103630 abstract "Solid dispersion systems of a poorly water-soluble drug, etoricoxib were prepared with poloxamer 188 in 1:0.5, 1:1.5 and 1:2.5 ratios and evaluated by FTIR, powder XRD and dissolution studies. Physical studies demonstrated a strong hydrogen bonding with significant decrease in the crystallinity and formation of amorphous etoricoxib in its binary systems. All binary systems of etoricoxib showed faster dissolution than pure drug alone (P < 0.001). However, 1:2.5 proportion of etoricoxib: poloxamer 188 showed superior performance (DE45: 71.27% ± 3.85) in enhancing solubility and dissolution rate of etoricoxib suggesting optimum ratio of the carrier." @default.
• W2048103630 created "2016-06-24" @default.
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• W2048103630 date "2009-04-27" @default.
• W2048103630 modified "2023-09-25" @default.
• W2048103630 title "Physicochemical investigation of the solid dispersion systems of etoricoxib with poloxamer 188" @default.
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• W2048103630 doi "https://doi.org/10.1080/10837450802683974" @default.
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