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• W2048103699 abstract "Nasopharyngeal carcinoma (NPC) is consistently associated with Epstein–Barr virus (EBV) and mostly classified as poorly differentiated squamous cell carcinoma or undifferentiated carcinoma with early metastasis and a rapidly progressive clinical course. The EBV-encoded latent proteins, Epstein–Barr nuclear antigen 1 (EBNA 1) and latent membrane proteins (LMPs), may be expressed in NPC, but their biological effects are poorly understood. EBNA 1 may predispose B lymphocytes to lymphomagenesis in transgenic mice, but its biological effects in NPC are still unknown. This study investigated the biological effects of EBNA 1 by expressing it in an EBV-negative NPC cell line (HONE-1), which was then inoculated into both nude and severe combined immunodeficiency mice. The EBNA 1 caused HONE-1 cells to grow in a less differentiated pattern and to progress more rapidly, as well as increasing their tumourigenicity and metastatic capability. These data suggest that EBNA 1 may play a critical role in the progressive evolution of NPC." @default.
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• W2048103699 date "1996-11-01" @default.
• W2048103699 modified "2023-10-12" @default.
• W2048103699 title "ENHANCED MALIGNANT PROGRESSION OF NASOPHARYNGEAL CARCINOMA CELLS MEDIATED BY THE EXPRESSION OF EPSTEIN-BARR NUCLEAR ANTIGEN 1IN VIVO" @default.
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• W2048103699 doi "https://doi.org/10.1002/(sici)1096-9896(199611)180:3<243::aid-path655>3.0.co;2-7" @default.
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