FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048113820> ?p ?o ?g. }

• W2048113820 endingPage "388" @default.
• W2048113820 startingPage "376" @default.
• W2048113820 abstract "A unique transgenic mouse line was generated by incorporating a minigene that contained a cone-specific human cone transducin alpha-subunit (GNAT2) promoter, an attenuated diphtheria toxin A (DTA) gene, and an enhancer element from human interphotoreceptor retinoid-binding protein (IRBP) gene. This transgenic mouse line is designated h-GNAT2pro-DTA. During postnatal retinal development, both transgenic and non-transgenic retinas showed similar morphology and thickness at P1. Between ages P8 and P30, all retinal layers became recognizable in non-transgenic and also in transgenic dorsal retinas. However, in the ventral retina of the transgenic mice the photoreceptor layers did not develop. This aberration occurred as a result of abnormal cellular development, rather than as a consequence of retinal degeneration. In adult transgenic animals, approximately 44% of the retina located dorsally appeared morphologically normal, whereas 32% of the retina located ventrally was completely lacking photoreceptor development. The 24% mid-retinal region exhibited transitional morphology containing malformed photoreceptors. At P360 or older, the thickness of retina layers was reduced in both dorsal and ventral regions. The abnormality observed in transgenic retinas involved mainly the photoreceptors; the other retinal cell types were all present in both dorsal and ventral retinas. Since the DTA gene was only expressed in cone cells, the absence of cone photoreceptors in the transgenic retina was to be expected. However, what was unexpected was the concomitant absence of rod photoreceptors in the ventral retina, suggesting that the presence of cones may be important for the development of rods. This new transgenic line can lead to better understanding of photoreceptor development, and may serve as a new animal model for studying photoreceptor-related retinal diseases." @default.
• W2048113820 created "2016-06-24" @default.
• W2048113820 creator A5001474001 @default.
• W2048113820 creator A5043430500 @default.
• W2048113820 creator A5054101735 @default.
• W2048113820 creator A5069929780 @default.
• W2048113820 creator A5073368543 @default.
• W2048113820 creator A5083539700 @default.
• W2048113820 creator A5085267115 @default.
• W2048113820 date "2005-10-01" @default.
• W2048113820 modified "2023-09-26" @default.
• W2048113820 title "Characterization of a transgenic mouse line lacking photoreceptor development within the ventral retina" @default.
• W2048113820 cites W1601380713 @default.
• W2048113820 cites W1772351760 @default.
• W2048113820 cites W1970928680 @default.
• W2048113820 cites W1974084948 @default.
• W2048113820 cites W1975744936 @default.
• W2048113820 cites W1992618284 @default.
• W2048113820 cites W2001974130 @default.
• W2048113820 cites W2007495564 @default.
• W2048113820 cites W2019071873 @default.
• W2048113820 cites W2019964232 @default.
• W2048113820 cites W2027753607 @default.
• W2048113820 cites W2030452669 @default.
• W2048113820 cites W2037390777 @default.
• W2048113820 cites W2059679976 @default.
• W2048113820 cites W2066556283 @default.
• W2048113820 cites W2075365540 @default.
• W2048113820 cites W2076644311 @default.
• W2048113820 cites W2077428235 @default.
• W2048113820 cites W2086607543 @default.
• W2048113820 cites W2099545629 @default.
• W2048113820 cites W2113401699 @default.
• W2048113820 cites W2133392010 @default.
• W2048113820 cites W2136938827 @default.
• W2048113820 cites W2160070769 @default.
• W2048113820 cites W2162996511 @default.
• W2048113820 cites W2166848619 @default.
• W2048113820 cites W2169217477 @default.
• W2048113820 doi "https://doi.org/10.1016/j.exer.2005.06.007" @default.
• W2048113820 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16054133" @default.
• W2048113820 hasPublicationYear "2005" @default.
• W2048113820 type Work @default.
• W2048113820 sameAs 2048113820 @default.
• W2048113820 citedByCount "4" @default.
• W2048113820 countsByYear W20481138202014 @default.
• W2048113820 countsByYear W20481138202018 @default.
• W2048113820 countsByYear W20481138202022 @default.
• W2048113820 crossrefType "journal-article" @default.
• W2048113820 hasAuthorship W2048113820A5001474001 @default.
• W2048113820 hasAuthorship W2048113820A5043430500 @default.
• W2048113820 hasAuthorship W2048113820A5054101735 @default.
• W2048113820 hasAuthorship W2048113820A5069929780 @default.
• W2048113820 hasAuthorship W2048113820A5073368543 @default.
• W2048113820 hasAuthorship W2048113820A5083539700 @default.
• W2048113820 hasAuthorship W2048113820A5085267115 @default.
• W2048113820 hasConcept C102230213 @default.
• W2048113820 hasConcept C104317684 @default.
• W2048113820 hasConcept C105702510 @default.
• W2048113820 hasConcept C131667965 @default.
• W2048113820 hasConcept C141035611 @default.
• W2048113820 hasConcept C149574991 @default.
• W2048113820 hasConcept C169760540 @default.
• W2048113820 hasConcept C202033177 @default.
• W2048113820 hasConcept C2777093970 @default.
• W2048113820 hasConcept C2780827179 @default.
• W2048113820 hasConcept C2781040256 @default.
• W2048113820 hasConcept C54355233 @default.
• W2048113820 hasConcept C55493867 @default.
• W2048113820 hasConcept C86803240 @default.
• W2048113820 hasConcept C95444343 @default.
• W2048113820 hasConceptScore W2048113820C102230213 @default.
• W2048113820 hasConceptScore W2048113820C104317684 @default.
• W2048113820 hasConceptScore W2048113820C105702510 @default.
• W2048113820 hasConceptScore W2048113820C131667965 @default.
• W2048113820 hasConceptScore W2048113820C141035611 @default.
• W2048113820 hasConceptScore W2048113820C149574991 @default.
• W2048113820 hasConceptScore W2048113820C169760540 @default.
• W2048113820 hasConceptScore W2048113820C202033177 @default.
• W2048113820 hasConceptScore W2048113820C2777093970 @default.
• W2048113820 hasConceptScore W2048113820C2780827179 @default.
• W2048113820 hasConceptScore W2048113820C2781040256 @default.
• W2048113820 hasConceptScore W2048113820C54355233 @default.
• W2048113820 hasConceptScore W2048113820C55493867 @default.
• W2048113820 hasConceptScore W2048113820C86803240 @default.
• W2048113820 hasConceptScore W2048113820C95444343 @default.
• W2048113820 hasIssue "4" @default.
• W2048113820 hasLocation W20481138201 @default.
• W2048113820 hasLocation W20481138202 @default.
• W2048113820 hasOpenAccess W2048113820 @default.
• W2048113820 hasPrimaryLocation W20481138201 @default.
• W2048113820 hasRelatedWork W176912078 @default.
• W2048113820 hasRelatedWork W1969180074 @default.
• W2048113820 hasRelatedWork W2039947995 @default.
• W2048113820 hasRelatedWork W2048113820 @default.
• W2048113820 hasRelatedWork W2462570590 @default.
• W2048113820 hasRelatedWork W2532287325 @default.
• W2048113820 hasRelatedWork W3045858918 @default.

• next