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- W2048115617 abstract "Publisher Summary This chapter elaborates the importance of norepinephrine as a central synaptic transmitter. The ultimate test of the function of central noradrenergic synapses must result from the selective activation of these terminals and from the detection of their activity patterns in the unrestrained experimental animal. Excitatory responses to NE in the cerebral cortex were found to be more frequent when the animal was unanesthetised or under the influence of halothane anesthesia, while inhibitory cortical responses were more frequent with barbiturate anesthesia. Similarly, the pH of the NE solution to be iontophoretically applied also takes on critical importance, as pH values less than 4 are associated with major increases in the frequency of excitatory NE responses. The NE-containing pathway has not been amenable to selective electrical activation for comparisons of qualitative and pharmacological results on the specified postsynaptic population of test neurons. It is found that synaptic effects which were subjectible to selective activation were neither exclusively NE-containing nor sensitive to NE antagonists." @default.
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- W2048115617 title "Norepinephrine as a central synaptic transmitter" @default.
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