FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048116688> ?p ?o ?g. }

• W2048116688 endingPage "28" @default.
• W2048116688 startingPage "5" @default.
• W2048116688 abstract "A critical review of the limited available evidence and the authors’ experience and judgment are used to summarize the role of cytochrome P450 (CYP) genetic variants in the pharmacokinetics of and clinical response to psychotropic medications. CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 genetic polymorphisms and their contributions to the metabolism of psychotropic drugs are reviewed. CYP1A2, CYP2B6 and CYP3A4 genotyping have limited current clinical utility. CYP2C9 genotyping has no utility in psychiatry. Psychiatrists should master tricyclic antidepressant (TCA) prescription, and if they use TCAs, they should have expertise in CYP2D6 and CYP2C19 genotyping and in TCA therapeutic drug monitoring (TDM) to safely dose TCAs. Practice guidelines recommend dose changes, TDM or alternate drugs for (1) CYP2C19 ultrarapid metabolizers (UM) taking citalopram or escitalopram; (2) CYP2C19 poor metabolizers (PMs) taking sertraline; (3) CYP2D6 PMs taking venlafaxine, aripiprazole, haloperidol, risperidone or zuclopenthixol; and (4) CYP2D6 UMs taking venlafaxine, aripiprazole, haloperidol, risperidone, zuclopenthixol or atomoxetine. According to the prescribing information, CYP2D6 PMs should receive 75 % of the average long-acting aripiprazole dose and pimozide doses >4 mg/day should not be prescribed without CYP2D6 genotyping. In a situation of limited evidence, there is need to use the available pharmacological mechanistic information for better personalizing treatment in psychiatry. This is best done by combining CYP genotyping with TDM. Clozapine and risperidone concentration-to-dose ratios are provided as two examples of this approach of how to integrate CYP genotyping and TDM in psychiatry. New studies are needed to verify that CYP2C19 PM genotyping may have potential to identify clozapine PMs and explain the lower clozapine metabolic capacity in East Asians." @default.
• W2048116688 created "2016-06-24" @default.
• W2048116688 creator A5056735832 @default.
• W2048116688 creator A5082054712 @default.
• W2048116688 date "2014-09-09" @default.
• W2048116688 modified "2023-10-06" @default.
• W2048116688 title "Clinical applications of CYP genotyping in psychiatry" @default.
• W2048116688 cites W1529088653 @default.
• W2048116688 cites W1544511641 @default.
• W2048116688 cites W1553294146 @default.
• W2048116688 cites W1581469242 @default.
• W2048116688 cites W1605204992 @default.
• W2048116688 cites W1734451748 @default.
• W2048116688 cites W1766115599 @default.
• W2048116688 cites W1832585901 @default.
• W2048116688 cites W1876387579 @default.
• W2048116688 cites W1914794436 @default.
• W2048116688 cites W1963984456 @default.
• W2048116688 cites W1966300584 @default.
• W2048116688 cites W1967079243 @default.
• W2048116688 cites W196795570 @default.
• W2048116688 cites W1968413239 @default.
• W2048116688 cites W1968898373 @default.
• W2048116688 cites W1971335539 @default.
• W2048116688 cites W1973644343 @default.
• W2048116688 cites W1974670279 @default.
• W2048116688 cites W1977023935 @default.
• W2048116688 cites W1977458296 @default.
• W2048116688 cites W1979238991 @default.
• W2048116688 cites W1980343502 @default.
• W2048116688 cites W1981246728 @default.
• W2048116688 cites W1981367166 @default.
• W2048116688 cites W1982611012 @default.
• W2048116688 cites W1982720679 @default.
• W2048116688 cites W1983144356 @default.
• W2048116688 cites W1984131408 @default.
• W2048116688 cites W1985324190 @default.
• W2048116688 cites W1985330332 @default.
• W2048116688 cites W1987838528 @default.
• W2048116688 cites W1988235147 @default.
• W2048116688 cites W1988973970 @default.
• W2048116688 cites W1989868874 @default.
• W2048116688 cites W1989897414 @default.
• W2048116688 cites W1992808445 @default.
• W2048116688 cites W1992824067 @default.
• W2048116688 cites W1992892112 @default.
• W2048116688 cites W1998225132 @default.
• W2048116688 cites W1999123251 @default.
• W2048116688 cites W2001657113 @default.
• W2048116688 cites W2004557299 @default.
• W2048116688 cites W2004978631 @default.
• W2048116688 cites W2007404873 @default.
• W2048116688 cites W2007781929 @default.
• W2048116688 cites W2007789051 @default.
• W2048116688 cites W2008486886 @default.
• W2048116688 cites W2009132689 @default.
• W2048116688 cites W2010427019 @default.
• W2048116688 cites W2010578682 @default.
• W2048116688 cites W2011444941 @default.
• W2048116688 cites W2012156333 @default.
• W2048116688 cites W2012407966 @default.
• W2048116688 cites W2012723101 @default.
• W2048116688 cites W2014756391 @default.
• W2048116688 cites W2014851780 @default.
• W2048116688 cites W2016827828 @default.
• W2048116688 cites W2019612987 @default.
• W2048116688 cites W2019651109 @default.
• W2048116688 cites W2019906796 @default.
• W2048116688 cites W2021635654 @default.
• W2048116688 cites W2021883998 @default.
• W2048116688 cites W2024724564 @default.
• W2048116688 cites W2025416272 @default.
• W2048116688 cites W2028166816 @default.
• W2048116688 cites W2028342467 @default.
• W2048116688 cites W2028837143 @default.
• W2048116688 cites W2028865413 @default.
• W2048116688 cites W2028938803 @default.
• W2048116688 cites W2029421599 @default.
• W2048116688 cites W2029986378 @default.
• W2048116688 cites W2029995473 @default.
• W2048116688 cites W2032164227 @default.
• W2048116688 cites W2032191165 @default.
• W2048116688 cites W2033042874 @default.
• W2048116688 cites W2038883472 @default.
• W2048116688 cites W2040194216 @default.
• W2048116688 cites W2041253701 @default.
• W2048116688 cites W2048244550 @default.
• W2048116688 cites W2048984349 @default.
• W2048116688 cites W2049875787 @default.
• W2048116688 cites W2051221453 @default.
• W2048116688 cites W2052090143 @default.
• W2048116688 cites W2060862944 @default.
• W2048116688 cites W2061376955 @default.
• W2048116688 cites W2062404230 @default.
• W2048116688 cites W2064096935 @default.
• W2048116688 cites W2066348531 @default.
• W2048116688 cites W2068398215 @default.
• W2048116688 cites W2070536631 @default.

• next