Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048126292> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2048126292 endingPage "194" @default.
- W2048126292 startingPage "191" @default.
- W2048126292 abstract "The collaborative study reported here was performed to evaluate the reliability of the skin corrosivity test in vitro when performed in independent laboratories. Twenty substances were examined in each of three participating laboratories and the results were compared with existing data from standard assays in vivo. The skin corrosivity test is based on the assumption that corrosive substances destroy the skin's natural outer protective barrier, the stratum corneum. Corrosive action in vitro is measured by a fall in the transcutaneous electrical resistance (TER) below a predetermined threshold. A refined test using a MgSO(4) electrolyte solution for TER measurements has recently been shown to reduce the number of false positive results in the test, while maintaining excellent predictive value for skin corrosive substances. Although in the present study there was some variation between laboratories in terms of the absolute mean TER values obtained, all 6 substances corrosive in vivo were correctly predicted by the three laboratories. The other 14 substances ranged from being non-irritant to severe skin irritants in vivo, but the test was unable to discriminate between these different categories in any of the three laboratories. However, these inter-laboratory comparisons demonstrate that the refined skin corrosivity test is a robust and reliable method in vitro for identifying potential skin corrosive substances." @default.
- W2048126292 created "2016-06-24" @default.
- W2048126292 creator A5004972450 @default.
- W2048126292 creator A5019104680 @default.
- W2048126292 creator A5021227577 @default.
- W2048126292 creator A5031854486 @default.
- W2048126292 creator A5040588262 @default.
- W2048126292 creator A5049589478 @default.
- W2048126292 creator A5058649245 @default.
- W2048126292 creator A5076569468 @default.
- W2048126292 creator A5078210692 @default.
- W2048126292 date "1992-05-01" @default.
- W2048126292 modified "2023-09-26" @default.
- W2048126292 title "The skin corrosivity test in vitro. Results of an inter-laboratory trial" @default.
- W2048126292 cites W2025018102 @default.
- W2048126292 cites W2065743516 @default.
- W2048126292 cites W2093562355 @default.
- W2048126292 cites W2135888869 @default.
- W2048126292 cites W94439474 @default.
- W2048126292 doi "https://doi.org/10.1016/0887-2333(92)90031-l" @default.
- W2048126292 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20732113" @default.
- W2048126292 hasPublicationYear "1992" @default.
- W2048126292 type Work @default.
- W2048126292 sameAs 2048126292 @default.
- W2048126292 citedByCount "28" @default.
- W2048126292 countsByYear W20481262922016 @default.
- W2048126292 countsByYear W20481262922017 @default.
- W2048126292 countsByYear W20481262922020 @default.
- W2048126292 crossrefType "journal-article" @default.
- W2048126292 hasAuthorship W2048126292A5004972450 @default.
- W2048126292 hasAuthorship W2048126292A5019104680 @default.
- W2048126292 hasAuthorship W2048126292A5021227577 @default.
- W2048126292 hasAuthorship W2048126292A5031854486 @default.
- W2048126292 hasAuthorship W2048126292A5040588262 @default.
- W2048126292 hasAuthorship W2048126292A5049589478 @default.
- W2048126292 hasAuthorship W2048126292A5058649245 @default.
- W2048126292 hasAuthorship W2048126292A5076569468 @default.
- W2048126292 hasAuthorship W2048126292A5078210692 @default.
- W2048126292 hasConcept C142724271 @default.
- W2048126292 hasConcept C150903083 @default.
- W2048126292 hasConcept C178790620 @default.
- W2048126292 hasConcept C185592680 @default.
- W2048126292 hasConcept C202751555 @default.
- W2048126292 hasConcept C20625102 @default.
- W2048126292 hasConcept C207001950 @default.
- W2048126292 hasConcept C2778370115 @default.
- W2048126292 hasConcept C33618052 @default.
- W2048126292 hasConcept C55493867 @default.
- W2048126292 hasConcept C71924100 @default.
- W2048126292 hasConcept C86803240 @default.
- W2048126292 hasConceptScore W2048126292C142724271 @default.
- W2048126292 hasConceptScore W2048126292C150903083 @default.
- W2048126292 hasConceptScore W2048126292C178790620 @default.
- W2048126292 hasConceptScore W2048126292C185592680 @default.
- W2048126292 hasConceptScore W2048126292C202751555 @default.
- W2048126292 hasConceptScore W2048126292C20625102 @default.
- W2048126292 hasConceptScore W2048126292C207001950 @default.
- W2048126292 hasConceptScore W2048126292C2778370115 @default.
- W2048126292 hasConceptScore W2048126292C33618052 @default.
- W2048126292 hasConceptScore W2048126292C55493867 @default.
- W2048126292 hasConceptScore W2048126292C71924100 @default.
- W2048126292 hasConceptScore W2048126292C86803240 @default.
- W2048126292 hasIssue "3" @default.
- W2048126292 hasLocation W20481262921 @default.
- W2048126292 hasLocation W20481262922 @default.
- W2048126292 hasOpenAccess W2048126292 @default.
- W2048126292 hasPrimaryLocation W20481262921 @default.
- W2048126292 hasRelatedWork W1970015963 @default.
- W2048126292 hasRelatedWork W2004909322 @default.
- W2048126292 hasRelatedWork W2013908504 @default.
- W2048126292 hasRelatedWork W2022955853 @default.
- W2048126292 hasRelatedWork W2084666230 @default.
- W2048126292 hasRelatedWork W2089784725 @default.
- W2048126292 hasRelatedWork W2151771966 @default.
- W2048126292 hasRelatedWork W2414342311 @default.
- W2048126292 hasRelatedWork W2806494979 @default.
- W2048126292 hasRelatedWork W2890575526 @default.
- W2048126292 hasVolume "6" @default.
- W2048126292 isParatext "false" @default.
- W2048126292 isRetracted "false" @default.
- W2048126292 magId "2048126292" @default.
- W2048126292 workType "article" @default.