FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048133028> ?p ?o ?g. }

• W2048133028 endingPage "171" @default.
• W2048133028 startingPage "162" @default.
• W2048133028 abstract "The expression of apolipoprotein E (apo E) is dramatically increased following peripheral nerve injury. This increased expression has been postulated to be negatively influenced by unknown mechanisms during subsequent axonal regeneration (Muller et al.: Science 228:499-501, 1985). The present study investigates the role of the regenerating axon in regulating apo E gene expression in two experimental paradigms which permit or prevent axonal regeneration in the adult rat sciatic nerve--the crush or permanent transection injuries. The nerves in these two models undergo axonal degeneration, demyelination, and Schwann cell proliferation; however, subsequent axonal regeneration and remyelination occur only in the distal segment of the crush-injured and not in the permanently transected nerve. The steady-state levels of apo E mRNA in both models increase sharply between 1 and 4 days and reach a maximum level at 12-14 days, which did not change significantly between 14 and 35 days after injury. No significant difference is observed in the steady-state levels of apo E mRNA between the crushed and permanently transected nerves as a function of time after injury. The steady-state protein level of apo E in the endoneurial segments initially increases, peaks at 14-21 days, and then decreases between 35 and 60 days after injury in both models. In contrast, the rate of newly translated and secreted apo E significantly increases by fourfold (P less than 0.005) between 35 and 60 days after permanent transection whereas it does not significantly differ at these times after crush injury. The increased rate of translation and secretion of apo E after transection compared to the constant rate observed after crush injury, together with the comparable steady-state levels of apo E mRNA and protein in both models, suggests translational or post-translational control, but not transcriptional and/or posttranscriptional control, by the regenerating axons. Furthermore, the increasing rate of biosynthesis and secretion of apo E after permanent transection concomitant with the decreasing steady-state levels of the protein suggests that apo E is either removed from the endoneurium or subsequently utilized or degraded by mechanisms that are independent from nerve regeneration." @default.
• W2048133028 created "2016-06-24" @default.
• W2048133028 creator A5026094613 @default.
• W2048133028 creator A5080381270 @default.
• W2048133028 date "1990-02-01" @default.
• W2048133028 modified "2023-09-26" @default.
• W2048133028 title "Regulation of apolipoprotein E gene expression after injury of the rat sciatic nerve" @default.
• W2048133028 cites W1489048499 @default.
• W2048133028 cites W1489708200 @default.
• W2048133028 cites W1492043593 @default.
• W2048133028 cites W1533371932 @default.
• W2048133028 cites W1574570946 @default.
• W2048133028 cites W1588900436 @default.
• W2048133028 cites W1604658771 @default.
• W2048133028 cites W1620258338 @default.
• W2048133028 cites W170055736 @default.
• W2048133028 cites W1775749144 @default.
• W2048133028 cites W1968670491 @default.
• W2048133028 cites W1972960247 @default.
• W2048133028 cites W1983326610 @default.
• W2048133028 cites W2004711215 @default.
• W2048133028 cites W2007138632 @default.
• W2048133028 cites W2011836510 @default.
• W2048133028 cites W2014669590 @default.
• W2048133028 cites W2023993559 @default.
• W2048133028 cites W2029007538 @default.
• W2048133028 cites W2034968148 @default.
• W2048133028 cites W2045170820 @default.
• W2048133028 cites W2047136450 @default.
• W2048133028 cites W2057176611 @default.
• W2048133028 cites W2058798908 @default.
• W2048133028 cites W2058951789 @default.
• W2048133028 cites W2060333964 @default.
• W2048133028 cites W2063968666 @default.
• W2048133028 cites W2072422194 @default.
• W2048133028 cites W2079637520 @default.
• W2048133028 cites W2091485657 @default.
• W2048133028 cites W2130763151 @default.
• W2048133028 cites W2132111287 @default.
• W2048133028 cites W2146195384 @default.
• W2048133028 cites W2147413218 @default.
• W2048133028 cites W2346531204 @default.
• W2048133028 cites W2411759529 @default.
• W2048133028 cites W4210985708 @default.
• W2048133028 cites W4232534952 @default.
• W2048133028 cites W981450589 @default.
• W2048133028 doi "https://doi.org/10.1002/jnr.490250203" @default.
• W2048133028 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2319626" @default.
• W2048133028 hasPublicationYear "1990" @default.
• W2048133028 type Work @default.
• W2048133028 sameAs 2048133028 @default.
• W2048133028 citedByCount "64" @default.
• W2048133028 countsByYear W20481330282013 @default.
• W2048133028 countsByYear W20481330282015 @default.
• W2048133028 countsByYear W20481330282017 @default.
• W2048133028 countsByYear W20481330282019 @default.
• W2048133028 countsByYear W20481330282020 @default.
• W2048133028 countsByYear W20481330282023 @default.
• W2048133028 crossrefType "journal-article" @default.
• W2048133028 hasAuthorship W2048133028A5026094613 @default.
• W2048133028 hasAuthorship W2048133028A5080381270 @default.
• W2048133028 hasConcept C104317684 @default.
• W2048133028 hasConcept C105580179 @default.
• W2048133028 hasConcept C105702510 @default.
• W2048133028 hasConcept C126322002 @default.
• W2048133028 hasConcept C134018914 @default.
• W2048133028 hasConcept C141071460 @default.
• W2048133028 hasConcept C150194340 @default.
• W2048133028 hasConcept C169760540 @default.
• W2048133028 hasConcept C171056886 @default.
• W2048133028 hasConcept C2775991916 @default.
• W2048133028 hasConcept C2776880756 @default.
• W2048133028 hasConcept C2777004073 @default.
• W2048133028 hasConcept C2777107032 @default.
• W2048133028 hasConcept C2777619251 @default.
• W2048133028 hasConcept C2778609137 @default.
• W2048133028 hasConcept C2779530196 @default.
• W2048133028 hasConcept C2781149210 @default.
• W2048133028 hasConcept C529278444 @default.
• W2048133028 hasConcept C55493867 @default.
• W2048133028 hasConcept C71924100 @default.
• W2048133028 hasConcept C86803240 @default.
• W2048133028 hasConcept C95444343 @default.
• W2048133028 hasConceptScore W2048133028C104317684 @default.
• W2048133028 hasConceptScore W2048133028C105580179 @default.
• W2048133028 hasConceptScore W2048133028C105702510 @default.
• W2048133028 hasConceptScore W2048133028C126322002 @default.
• W2048133028 hasConceptScore W2048133028C134018914 @default.
• W2048133028 hasConceptScore W2048133028C141071460 @default.
• W2048133028 hasConceptScore W2048133028C150194340 @default.
• W2048133028 hasConceptScore W2048133028C169760540 @default.
• W2048133028 hasConceptScore W2048133028C171056886 @default.
• W2048133028 hasConceptScore W2048133028C2775991916 @default.
• W2048133028 hasConceptScore W2048133028C2776880756 @default.
• W2048133028 hasConceptScore W2048133028C2777004073 @default.
• W2048133028 hasConceptScore W2048133028C2777107032 @default.
• W2048133028 hasConceptScore W2048133028C2777619251 @default.
• W2048133028 hasConceptScore W2048133028C2778609137 @default.

• next