FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048138263> ?p ?o ?g. }

• W2048138263 endingPage "136" @default.
• W2048138263 startingPage "125" @default.
• W2048138263 abstract "The ability to selectively remove the structurally most relevant components of arterial wall tissues such as collagen and elastin enables ex vivo biomechanical testing of the remaining tissues, with the aim of assessing their individual mechanical contributions. Resulting passive material parameters can be utilized in mathematical models of the cardiovascular system. Using eighteen wall specimens fromnon-atherosclerotic human abdominal aortas (55±11 years; 9 female, 9 male), we tested enzymatic approaches for the selective digestion of collagen and elastin, focusing on their application to human abdominal aortic wall tissues from different patients with varying sample morphologies. The study resulted in an improved protocol for elastin removal, showing how the enzymatic process is affected by inadequate addition of trypsin inhibitor. We applied the resulting protocol to circumferential and axial specimens from the media and the adventitia, and performed cyclic uniaxial extension tests in the physiological and supra-physiological loading domain. The collagenase-treated samples showed a (linear) response without distinct softening behavior, while the elastase-treated samples exhibited a nonlinear, anisotropic response with pronounced remanent deformations (continuous softening), presumably caused by some sliding of collagen fibers within the damaged regions of the collagen network. In addition, our data showed that the stiffness in the initial linear stress–stretch regime at low loads is lower in elastin-free tissue compared to control samples (i.e. collagen uncrimping requires less force than the stretching of elastin), experimentally confirming that elastin is responsible for the initial stiffness in elastic arteries. Utilizing a continuum mechanical description to mathematically capture the experimental results we concluded that the inclusion of a damage model for the non-collagenous matrix material is, in general, not necessary. To model the softening behavior, continuous damage was included in the fibers by adding a damage variable which led to remanent strains through the consideration of damage." @default.
• W2048138263 created "2016-06-24" @default.
• W2048138263 creator A5006819872 @default.
• W2048138263 creator A5050505742 @default.
• W2048138263 creator A5052701354 @default.
• W2048138263 creator A5062380861 @default.
• W2048138263 creator A5067096341 @default.
• W2048138263 date "2015-04-01" @default.
• W2048138263 modified "2023-09-23" @default.
• W2048138263 title "Selective enzymatic removal of elastin and collagen from human abdominal aortas: Uniaxial mechanical response and constitutive modeling" @default.
• W2048138263 cites W1500831274 @default.
• W2048138263 cites W1972838533 @default.
• W2048138263 cites W1976844054 @default.
• W2048138263 cites W1977063638 @default.
• W2048138263 cites W1979055449 @default.
• W2048138263 cites W1987603011 @default.
• W2048138263 cites W1989918629 @default.
• W2048138263 cites W1991005691 @default.
• W2048138263 cites W2011322260 @default.
• W2048138263 cites W2012160048 @default.
• W2048138263 cites W2012475038 @default.
• W2048138263 cites W2020271815 @default.
• W2048138263 cites W2025234339 @default.
• W2048138263 cites W2025790361 @default.
• W2048138263 cites W2026940714 @default.
• W2048138263 cites W2027635580 @default.
• W2048138263 cites W2031448916 @default.
• W2048138263 cites W2031684656 @default.
• W2048138263 cites W2039354854 @default.
• W2048138263 cites W2041178530 @default.
• W2048138263 cites W2042299302 @default.
• W2048138263 cites W2043872162 @default.
• W2048138263 cites W2060315576 @default.
• W2048138263 cites W2060622258 @default.
• W2048138263 cites W2065530999 @default.
• W2048138263 cites W2070068353 @default.
• W2048138263 cites W2076579154 @default.
• W2048138263 cites W2081078015 @default.
• W2048138263 cites W2087335616 @default.
• W2048138263 cites W2111671046 @default.
• W2048138263 cites W2112123157 @default.
• W2048138263 cites W2116463491 @default.
• W2048138263 cites W2125408508 @default.
• W2048138263 cites W2128354492 @default.
• W2048138263 cites W2128531352 @default.
• W2048138263 cites W2141155068 @default.
• W2048138263 cites W2147355064 @default.
• W2048138263 cites W2156815041 @default.
• W2048138263 cites W2158968597 @default.
• W2048138263 cites W2166724685 @default.
• W2048138263 cites W2166739553 @default.
• W2048138263 cites W2406549739 @default.
• W2048138263 doi "https://doi.org/10.1016/j.actbio.2015.01.003" @default.
• W2048138263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25623592" @default.
• W2048138263 hasPublicationYear "2015" @default.
• W2048138263 type Work @default.
• W2048138263 sameAs 2048138263 @default.
• W2048138263 citedByCount "58" @default.
• W2048138263 countsByYear W20481382632015 @default.
• W2048138263 countsByYear W20481382632016 @default.
• W2048138263 countsByYear W20481382632017 @default.
• W2048138263 countsByYear W20481382632018 @default.
• W2048138263 countsByYear W20481382632019 @default.
• W2048138263 countsByYear W20481382632020 @default.
• W2048138263 countsByYear W20481382632021 @default.
• W2048138263 countsByYear W20481382632022 @default.
• W2048138263 countsByYear W20481382632023 @default.
• W2048138263 crossrefType "journal-article" @default.
• W2048138263 hasAuthorship W2048138263A5006819872 @default.
• W2048138263 hasAuthorship W2048138263A5050505742 @default.
• W2048138263 hasAuthorship W2048138263A5052701354 @default.
• W2048138263 hasAuthorship W2048138263A5062380861 @default.
• W2048138263 hasAuthorship W2048138263A5067096341 @default.
• W2048138263 hasConcept C105702510 @default.
• W2048138263 hasConcept C12554922 @default.
• W2048138263 hasConcept C136229726 @default.
• W2048138263 hasConcept C142724271 @default.
• W2048138263 hasConcept C159985019 @default.
• W2048138263 hasConcept C181199279 @default.
• W2048138263 hasConcept C185592680 @default.
• W2048138263 hasConcept C192562407 @default.
• W2048138263 hasConcept C2776716733 @default.
• W2048138263 hasConcept C2778394429 @default.
• W2048138263 hasConcept C2779372316 @default.
• W2048138263 hasConcept C2779869378 @default.
• W2048138263 hasConcept C2780299668 @default.
• W2048138263 hasConcept C2781044401 @default.
• W2048138263 hasConcept C2781098093 @default.
• W2048138263 hasConcept C55493867 @default.
• W2048138263 hasConcept C71924100 @default.
• W2048138263 hasConcept C86803240 @default.
• W2048138263 hasConceptScore W2048138263C105702510 @default.
• W2048138263 hasConceptScore W2048138263C12554922 @default.
• W2048138263 hasConceptScore W2048138263C136229726 @default.
• W2048138263 hasConceptScore W2048138263C142724271 @default.
• W2048138263 hasConceptScore W2048138263C159985019 @default.
• W2048138263 hasConceptScore W2048138263C181199279 @default.
• W2048138263 hasConceptScore W2048138263C185592680 @default.

• next