FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048149558> ?p ?o ?g. }

• W2048149558 endingPage "5" @default.
• W2048149558 startingPage "1" @default.
• W2048149558 abstract "Amyotrophic lateral sclerosis (ALS) or motor neuron disease is an adult-onset progressive neurodegenerative disorder. ALS-CSF has been shown to produce toxic effects on motor neuron cells like aberrant neurofilament phosphorylation and morphological alterations of nuclear and soma size. Our current study was designed to investigate the neuroprotective role of platelet derived growth factor (PDGF) in reverting the adverse effects produced by ALS-CSF.Our present study was carried out to determine the restorative potential of PDGF on the toxic effects of ALS-CSF on NSC motor neuron cells from patients. Therefore the cells were divided in to three groups: (a) normal control (NC) - the cells were not exposed to ALS-CSF; (b) ALS group - the cells were exposed to ALS-CSF; (c) NALS group - the cells were exposed to non ALS CSF. Further each of these groups was supplemented with PDGF.We observed that the mean area of nucleus and cell soma of the differentiated NSC motor neuron cells was significantly reduced in the cells exposed to ALS-CSF. We also observed that subsequent treatment with PDGF restored the soma area and nucleus of the ALS-CSF exposed cells significantly. Taken together, we show that supplementation with PDGF restores the morphological changes induced by ALS-CSF and PDGF may play a significant role in protecting motor neurons from apoptosis in ALS and thereby it promoting the cell survival." @default.
• W2048149558 created "2016-06-24" @default.
• W2048149558 creator A5001753331 @default.
• W2048149558 creator A5002408938 @default.
• W2048149558 creator A5024125336 @default.
• W2048149558 creator A5054627972 @default.
• W2048149558 creator A5063957187 @default.
• W2048149558 creator A5070498025 @default.
• W2048149558 creator A5089744853 @default.
• W2048149558 creator A5090731919 @default.
• W2048149558 date "2014-05-01" @default.
• W2048149558 modified "2023-09-27" @default.
• W2048149558 title "Role of platelet derived growth factor (PDGF) in reverting neuronal nuclear and soma size alterations in NSC-34 cells exposed to cerebrospinal fluid from amyotrophic lateral sclerosis patients" @default.
• W2048149558 cites W1894493322 @default.
• W2048149558 cites W1974951860 @default.
• W2048149558 cites W1984869034 @default.
• W2048149558 cites W1989533240 @default.
• W2048149558 cites W2008186081 @default.
• W2048149558 cites W2010233410 @default.
• W2048149558 cites W2021856689 @default.
• W2048149558 cites W2038496797 @default.
• W2048149558 cites W2073864172 @default.
• W2048149558 cites W2148371225 @default.
• W2048149558 cites W2156171273 @default.
• W2048149558 cites W2157123931 @default.
• W2048149558 cites W2160054680 @default.
• W2048149558 cites W4236884331 @default.
• W2048149558 cites W91904431 @default.
• W2048149558 doi "https://doi.org/10.1016/j.clineuro.2014.02.004" @default.
• W2048149558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24731566" @default.
• W2048149558 hasPublicationYear "2014" @default.
• W2048149558 type Work @default.
• W2048149558 sameAs 2048149558 @default.
• W2048149558 citedByCount "8" @default.
• W2048149558 countsByYear W20481495582017 @default.
• W2048149558 countsByYear W20481495582018 @default.
• W2048149558 countsByYear W20481495582021 @default.
• W2048149558 countsByYear W20481495582022 @default.
• W2048149558 countsByYear W20481495582023 @default.
• W2048149558 crossrefType "journal-article" @default.
• W2048149558 hasAuthorship W2048149558A5001753331 @default.
• W2048149558 hasAuthorship W2048149558A5002408938 @default.
• W2048149558 hasAuthorship W2048149558A5024125336 @default.
• W2048149558 hasAuthorship W2048149558A5054627972 @default.
• W2048149558 hasAuthorship W2048149558A5063957187 @default.
• W2048149558 hasAuthorship W2048149558A5070498025 @default.
• W2048149558 hasAuthorship W2048149558A5089744853 @default.
• W2048149558 hasAuthorship W2048149558A5090731919 @default.
• W2048149558 hasConcept C118552586 @default.
• W2048149558 hasConcept C126322002 @default.
• W2048149558 hasConcept C142724271 @default.
• W2048149558 hasConcept C157207234 @default.
• W2048149558 hasConcept C169760540 @default.
• W2048149558 hasConcept C170493617 @default.
• W2048149558 hasConcept C180361614 @default.
• W2048149558 hasConcept C204232928 @default.
• W2048149558 hasConcept C25498285 @default.
• W2048149558 hasConcept C2775960820 @default.
• W2048149558 hasConcept C2776752467 @default.
• W2048149558 hasConcept C2778794669 @default.
• W2048149558 hasConcept C2779134260 @default.
• W2048149558 hasConcept C2779617337 @default.
• W2048149558 hasConcept C2779651940 @default.
• W2048149558 hasConcept C2780596555 @default.
• W2048149558 hasConcept C2781294074 @default.
• W2048149558 hasConcept C71924100 @default.
• W2048149558 hasConcept C86803240 @default.
• W2048149558 hasConceptScore W2048149558C118552586 @default.
• W2048149558 hasConceptScore W2048149558C126322002 @default.
• W2048149558 hasConceptScore W2048149558C142724271 @default.
• W2048149558 hasConceptScore W2048149558C157207234 @default.
• W2048149558 hasConceptScore W2048149558C169760540 @default.
• W2048149558 hasConceptScore W2048149558C170493617 @default.
• W2048149558 hasConceptScore W2048149558C180361614 @default.
• W2048149558 hasConceptScore W2048149558C204232928 @default.
• W2048149558 hasConceptScore W2048149558C25498285 @default.
• W2048149558 hasConceptScore W2048149558C2775960820 @default.
• W2048149558 hasConceptScore W2048149558C2776752467 @default.
• W2048149558 hasConceptScore W2048149558C2778794669 @default.
• W2048149558 hasConceptScore W2048149558C2779134260 @default.
• W2048149558 hasConceptScore W2048149558C2779617337 @default.
• W2048149558 hasConceptScore W2048149558C2779651940 @default.
• W2048149558 hasConceptScore W2048149558C2780596555 @default.
• W2048149558 hasConceptScore W2048149558C2781294074 @default.
• W2048149558 hasConceptScore W2048149558C71924100 @default.
• W2048149558 hasConceptScore W2048149558C86803240 @default.
• W2048149558 hasLocation W20481495581 @default.
• W2048149558 hasLocation W20481495582 @default.
• W2048149558 hasOpenAccess W2048149558 @default.
• W2048149558 hasPrimaryLocation W20481495581 @default.
• W2048149558 hasRelatedWork W165332697 @default.
• W2048149558 hasRelatedWork W1970642506 @default.
• W2048149558 hasRelatedWork W2013158197 @default.
• W2048149558 hasRelatedWork W2048149558 @default.
• W2048149558 hasRelatedWork W2103800348 @default.
• W2048149558 hasRelatedWork W2530589371 @default.
• W2048149558 hasRelatedWork W2678922020 @default.
• W2048149558 hasRelatedWork W4376630746 @default.

• next