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- W2048153007 abstract "Significance Argonaute (Ago) proteins are the key component of the RNA-induced silencing complex (RISC) and mediate RNA interference (RNAi) in association with small RNAs. Although overall the mechanism of RNAi is well understood, many molecular details of this complex process are not. The implementation of pre-steady-state kinetic techniques enabled us to develop a comprehensive minimal mechanistic model for human Ago 2 (hAgo2)-mediated target RNA binding and cleavage, dissecting binary as well as ternary complex formation and target RNA cleavage into individual substeps. The model presented provides in-depth insights into the complicated interplay of hAgo2 with small RNAs and corresponding target molecules, which in combination with available X-ray structures will eventually lead to better understanding of the underlying mechanisms of RNAi." @default.
- W2048153007 created "2016-06-24" @default.
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- W2048153007 date "2013-10-07" @default.
- W2048153007 modified "2023-10-15" @default.
- W2048153007 title "Minimal mechanistic model of siRNA-dependent target RNA slicing by recombinant human Argonaute 2 protein" @default.
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- W2048153007 doi "https://doi.org/10.1073/pnas.1217838110" @default.
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