FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048153886> ?p ?o ?g. }

• W2048153886 endingPage "186" @default.
• W2048153886 startingPage "179" @default.
• W2048153886 abstract "Epidermal growth factor (EGF) and Tamm-Horsfall protein (THP) are synthesized in the kidneys by the distal tubular cells and excreted into urine. The urinary excretion of these peptides has been suggested as a potential index for distal tubular function. The urinary excretion rates of EGF and THP were examined in three groups of rats with increased renal excretion of urine: uninephrectomy, non-osmotic polyuria and diabetic osmotic polyuria. Twenty-four hour urine samples were obtained after 7, 14 and 21 days. The urinary volume per kidney was doubled in uninephrectomy when compared to controls. There was a seven-fold increase in urinary volume in rats with non-osmotic polyuria and diabetic osmotic polyuria, as compared to controls. Uninephrectomy, non-osmotic polyuria and diabetes all affected the urinary excretion of EGF and THP differently. The EGF excretion in uninephrectomized rats was 60-80% of that of the controls, whereas THP excretion was unchanged, indicating that EGF excretion varied with renal tissue mass. Non-osmotic polyuria caused a five-fold increase in THP excretion but no change in EGF excretion. THP excretion in the diabetic rats was increased three-fold after 21 days when compared to controls, whereas EGF excretion was decreased when expressed per kidney weight. Immunohistochemistry demonstrated that EGF and THP were colocalized in the thick ascending limbs of Henle's loops and distal tubules in all five groups of rats. In conclusion, the EGF excretion appears to follow renal tissue mass and seems independent of urinary volume, whereas THP excretion is dependent mainly on urinary volume. This has implications for the use of EGF and/or THP excretion rates as an indicator for distal tubular function." @default.
• W2048153886 created "2016-06-24" @default.
• W2048153886 creator A5006277207 @default.
• W2048153886 creator A5007927943 @default.
• W2048153886 creator A5012408833 @default.
• W2048153886 creator A5060723381 @default.
• W2048153886 creator A5063215371 @default.
• W2048153886 date "1997-10-01" @default.
• W2048153886 modified "2023-10-05" @default.
• W2048153886 title "Urinary excretion of epidermal growth factor and Tamm–Horsfall protein in three rat models with increased renal excretion of urine" @default.
• W2048153886 cites W108682491 @default.
• W2048153886 cites W1964737507 @default.
• W2048153886 cites W1966959821 @default.
• W2048153886 cites W1969415422 @default.
• W2048153886 cites W1985703856 @default.
• W2048153886 cites W1985786096 @default.
• W2048153886 cites W1987047294 @default.
• W2048153886 cites W1992495490 @default.
• W2048153886 cites W2000878997 @default.
• W2048153886 cites W2014380037 @default.
• W2048153886 cites W2030534014 @default.
• W2048153886 cites W2035563619 @default.
• W2048153886 cites W2036390336 @default.
• W2048153886 cites W2040415928 @default.
• W2048153886 cites W2051381725 @default.
• W2048153886 cites W2067431949 @default.
• W2048153886 cites W2072107182 @default.
• W2048153886 cites W2095529051 @default.
• W2048153886 cites W2124397815 @default.
• W2048153886 cites W2128678765 @default.
• W2048153886 cites W2312515686 @default.
• W2048153886 cites W2461856286 @default.
• W2048153886 cites W4211062907 @default.
• W2048153886 doi "https://doi.org/10.1016/s0167-0115(97)01058-6" @default.
• W2048153886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9652978" @default.
• W2048153886 hasPublicationYear "1997" @default.
• W2048153886 type Work @default.
• W2048153886 sameAs 2048153886 @default.
• W2048153886 citedByCount "26" @default.
• W2048153886 countsByYear W20481538862012 @default.
• W2048153886 countsByYear W20481538862015 @default.
• W2048153886 countsByYear W20481538862016 @default.
• W2048153886 countsByYear W20481538862018 @default.
• W2048153886 countsByYear W20481538862019 @default.
• W2048153886 countsByYear W20481538862022 @default.
• W2048153886 countsByYear W20481538862023 @default.
• W2048153886 crossrefType "journal-article" @default.
• W2048153886 hasAuthorship W2048153886A5006277207 @default.
• W2048153886 hasAuthorship W2048153886A5007927943 @default.
• W2048153886 hasAuthorship W2048153886A5012408833 @default.
• W2048153886 hasAuthorship W2048153886A5060723381 @default.
• W2048153886 hasAuthorship W2048153886A5063215371 @default.
• W2048153886 hasConcept C10146269 @default.
• W2048153886 hasConcept C126322002 @default.
• W2048153886 hasConcept C134018914 @default.
• W2048153886 hasConcept C159641895 @default.
• W2048153886 hasConcept C161457703 @default.
• W2048153886 hasConcept C170493617 @default.
• W2048153886 hasConcept C185592680 @default.
• W2048153886 hasConcept C2776362946 @default.
• W2048153886 hasConcept C2780026642 @default.
• W2048153886 hasConcept C2780091579 @default.
• W2048153886 hasConcept C2780180277 @default.
• W2048153886 hasConcept C555293320 @default.
• W2048153886 hasConcept C71924100 @default.
• W2048153886 hasConcept C74460091 @default.
• W2048153886 hasConceptScore W2048153886C10146269 @default.
• W2048153886 hasConceptScore W2048153886C126322002 @default.
• W2048153886 hasConceptScore W2048153886C134018914 @default.
• W2048153886 hasConceptScore W2048153886C159641895 @default.
• W2048153886 hasConceptScore W2048153886C161457703 @default.
• W2048153886 hasConceptScore W2048153886C170493617 @default.
• W2048153886 hasConceptScore W2048153886C185592680 @default.
• W2048153886 hasConceptScore W2048153886C2776362946 @default.
• W2048153886 hasConceptScore W2048153886C2780026642 @default.
• W2048153886 hasConceptScore W2048153886C2780091579 @default.
• W2048153886 hasConceptScore W2048153886C2780180277 @default.
• W2048153886 hasConceptScore W2048153886C555293320 @default.
• W2048153886 hasConceptScore W2048153886C71924100 @default.
• W2048153886 hasConceptScore W2048153886C74460091 @default.
• W2048153886 hasIssue "2-3" @default.
• W2048153886 hasLocation W20481538861 @default.
• W2048153886 hasLocation W20481538862 @default.
• W2048153886 hasOpenAccess W2048153886 @default.
• W2048153886 hasPrimaryLocation W20481538861 @default.
• W2048153886 hasRelatedWork W1772468801 @default.
• W2048153886 hasRelatedWork W1979258691 @default.
• W2048153886 hasRelatedWork W2018368842 @default.
• W2048153886 hasRelatedWork W2019138461 @default.
• W2048153886 hasRelatedWork W2021560856 @default.
• W2048153886 hasRelatedWork W2032639135 @default.
• W2048153886 hasRelatedWork W2044826694 @default.
• W2048153886 hasRelatedWork W2048153886 @default.
• W2048153886 hasRelatedWork W2058424427 @default.
• W2048153886 hasRelatedWork W2748952813 @default.
• W2048153886 hasVolume "72" @default.
• W2048153886 isParatext "false" @default.
• W2048153886 isRetracted "false" @default.

• next