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- W2048161191 abstract "Abstract A gradual breakdown in vivo of the polyribosomes in the post-mitochondrial supernatant of normal and regenerating rat liver to monomers and dimers is observed up to 5 h after a single injection (110 mg/kg) of 8-azaguanine. There follows a recovery phase, lasting in excess of 12 h, during which the size distribution returns to normal. During the recovery phase the size distribution is similar to that of neoplastic liver. Low doses of actinomycin D partially inhibits the 8-azaguanine-induced breakdown of the polyribosomes. [14C]Orotic acid was incorporated into the ribosomes of the monomer, dimer and polyribosome pools at equal rates during both the breakdown and recovery phases, suggesting that the pools were interconvertable. The data are consistent with the substitution of 8-azaguanine for guanine in an RNA component(s) which has a relatively short half-life (cf. ribosomal RNA) and which normally contributes to the integrity of the polyribosome." @default.
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- W2048161191 date "1967-04-01" @default.
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- W2048161191 title "Polyribosome breakdown in rat liver following administration of 8-azaguanine" @default.
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- W2048161191 doi "https://doi.org/10.1016/0005-2787(67)90491-1" @default.
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