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• W2048170070 endingPage "3302" @default.
• W2048170070 startingPage "3293" @default.
• W2048170070 abstract "Genomic instability has been considered to be one of the prominent factors for carcinogenesis and the development of a number of degenerative disorders, predominantly related to the aging. The cellular machineries involved in the maintenance of genomic integrity such as DNA repair and DNA damage responses are extensively characterized by a large number of studies. The failure of proper actions of such cellular machineries may lead to the devastating effects mostly inducing cancer or premature aging, even with no acute exogenous DNA damage stimuli. In this review, we especially focus on the pathophysiological aspects of the defective DNA damage responses in carcinogenesis and premature aging. Clear understanding the causes of carcinogenesis and age-related degenerative diseases will provide novel and efficient approaches for prevention and rational treatment of cancer and premature aging." @default.
• W2048170070 created "2016-06-24" @default.
• W2048170070 creator A5020752812 @default.
• W2048170070 creator A5042191727 @default.
• W2048170070 date "2013-08-02" @default.
• W2048170070 modified "2023-10-09" @default.
• W2048170070 title "The accumulation of DNA repair defects is the molecular origin of carcinogenesis" @default.
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